A kind of hydrophilic antigen and/or hydrophobic antigen vaccine delivery system and preparation method thereof
A delivery system and hydrophobic technology, applied in the field of vaccine delivery system and its preparation, can solve the problem of poor targeted delivery to lymph nodes
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Embodiment 1
[0052] Dissolve 6 g of cetyltrimethylammonium chloride and 0.18 g of triethanolamine in sterile water, heat and stir for 1 h, add 20 ml of tetraethylorthosilicate / cyclohexane solution (v / v, 5%), and dissolve The stirring speed was adjusted to 180rpm, and the reaction was 24 hours. The product was formed in the water phase. The water phase was diluted with ethanol, centrifuged, and the precipitate was collected. The precipitate was washed twice with absolute ethanol, and resuspended with 40 ml of ammonium nitrate / ethanol solution (w / v, 0.6%), heated and stirred to reflux for 6 h to remove the template agent cetyltrimethylammonium chloride; the refluxed mesoporous silica was collected by centrifugation and freeze-dried.
Embodiment 2
[0054] Dissolve 6 g of cetyltrimethylammonium chloride and 0.8 g of triethanolamine in sterile water, heat and stir for 1 h, add 20 ml of tetraethyl orthosilicate / naphthalene solution (v / v, 20%), and stir Adjust the speed to 300rpm, react for 12 hours, and the product is formed in the water phase. The water phase is diluted with ethanol, centrifuged, and the precipitate is collected. The precipitate is washed twice with absolute ethanol, and resuspended with 40 ml of ammonium nitrate / ethanol solution (w / v , 0.6%), heated and stirred under reflux for 6 h to remove the template agent cetyltrimethylammonium chloride; the refluxed mesoporous silica was collected by centrifugation and freeze-dried.
Embodiment 3
[0056] Dissolve 6 g of cetyltrimethylammonium chloride and 0.05 g of triethanolamine in sterile water, heat and stir for 1 h, add 20 ml of tetraethylorthosilicate / naphthalene solution (v / v, 40%), and stir Adjust the speed to 100 rpm, react for 1 h, and the product is formed in the water phase. The water phase is diluted with ethanol, centrifuged, and the precipitate is collected. The precipitate is washed twice with absolute ethanol, and resuspended with 40 ml of ammonium nitrate / ethanol solution (w / v, 0.6%), heated and stirred to reflux for 6 h to remove the template agent cetyltrimethylammonium chloride; the refluxed mesoporous silica was collected by centrifugation and freeze-dried.
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