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Novel nano fiber vascular stent material with double-drug loading and staged slow release functions and preparation method of thereof

A nanofiber and vascular stent technology, which is applied in the field of new nanofiber vascular stent materials and their preparation, can solve the problems that there are no nanofiber vascular stent materials with dual-drug loading and staged sustained release functions, and reduce the risk of thrombosis. risk, inhibit tumor growth, avoid the effect of clogging blood vessels

Active Publication Date: 2020-09-01
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no domestic and foreign literature and patent reports on nanofibrous vascular scaffold materials with dual-drug loading and step-by-step sustained-release functions

Method used

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  • Novel nano fiber vascular stent material with double-drug loading and staged slow release functions and preparation method of thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0019] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 5kV), the spinning solidification distance is 10cm, the needle size is 0.2mm, and the injection speed is 0.2mms –1 , translation speed is 100mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying t...

Embodiment 2

[0023] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0024] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 10kV), the spinning solidification distance is 15cm, the needle size is 0.4mm, and the jetting speed is 0.4mms –1 , translation speed is 200mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying tr...

Embodiment 3

[0028] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0029] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 15kV), the spinning solidification distance is 20cm, the needle size is 0.6mm, and the jetting speed is 0.6mms –1 , translation speed is 300mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying tr...

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Abstract

The invention discloses a novel nano fiber vascular stent material with double-drug loading and staged slow release functions and a preparation method thereof. Immunoglobulin lgG antibodies coupled tothe outer layer of the stent material stimulate cells to form epithelial tissues, so that the risk of thrombus formation is reduced; due to decomposition of polylactic acid on the outer layer of thescaffold, penicillin loaded on polylactic acid is slowly released, and division and growth of abnormal cells are inhibited. Due to decomposition of a nitric oxide donor combined with chitosan on the inner layer of the stent, nitric oxide free radicals are slowly released so as to expand blood vessels and inhibit tumor growth. The stent material has double drugs: loaded penicillin and nitric oxideand has a function of slowly releasing drugs in different stages layer by layer; the stent is expected to serve as a novel multifunctional vascular stent in clinic and can be implanted into coronary artery blood vessels of a patient, and multiple postoperative treatment effects of supporting focus blood vessels, reducing thrombus risks, inhibiting cytopathy, expanding blood vessels through free radicals, inhibiting tumor growth and the like are achieved.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanometer drug carriers and vascular stent materials, and in particular relates to a novel nanofiber vascular stent material with dual-drug loading and step-by-step slow-release functions and a preparation method thereof. Background technique [0002] After cardiac vasodilation surgery, 30% of patients will face narrowing of blood vessels within six months. Since the patient's blood vessels cannot recover normally after the operation, many cells will be produced to block the blood vessels, resulting in the need for another bypass surgery or angioplasty. In order to avoid vascular narrowing and blockage after surgery, an internal stent needs to be placed in the lesion to support the stenotic occluded vessel, prevent the elastic retraction and reshaping of the vessel, and maintain the smooth blood flow in the lumen. In the early 1980s, doctors envisioned using stents to open up the stiff, na...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/02A61L31/14A61L31/16
CPCA61L31/042A61L31/06A61L31/028A61L31/16A61L31/148A61L31/14A61L2300/102A61L2300/256A61L2300/406A61L2300/42A61L2300/416A61L2300/604C08L5/08C08L67/04
Inventor 桂日军孙泽君金辉
Owner QINGDAO UNIV
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