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Citric acid hemodialysis concentrate for supplementing vitamin D

A technology for vitamin supplementation and hemodialysis, which is applied in the field of citrate hemodialysis concentrate to achieve high survival rate and prevent loss.

Inactive Publication Date: 2020-08-18
甘肃锦东医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] At present, the methods of clinically supplementing vitamin D are mainly oral vitamin D capsules and intravenous vitamin D injections. There are no other methods and products for supplementing vitamin D, and there is no special method of hemodialysis for the treatment of mineral and bone metabolism disorders and Its complications, especially the citrate hemodialysis concentrate formula and products supplemented with vitamin D in chronic kidney disease patients with diabetes are still blank

Method used

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  • Citric acid hemodialysis concentrate for supplementing vitamin D
  • Citric acid hemodialysis concentrate for supplementing vitamin D
  • Citric acid hemodialysis concentrate for supplementing vitamin D

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Before dialysis:

[0034] Normal saline side: 5L normal saline, add paricalcitol active vitamin D0.15g;

[0035] Dialysate side: the formula of the dialysis concentrate is selected from the formula of Example 1 in Table 4, wherein the pH regulator is citric acid, and is prepared after dilution according to A:B:water=1:1.225:32.775 The hemodialysate, the ion concentration in the hemodialysate is as shown in Table 5:

[0036] Ion concentration and pH value in dialysate after dilution in Table 5 Example 1

[0037]

[0038] (2) After dialysis

[0039] The content of paricalcitol active vitamin D in normal saline and dialysate after dialysis was detected with an automatic biochemical analyzer, and the results are shown in Table 6.

[0040] Table 6 Vitamin D content in blood and dialysate after dialysis (unit: g / 5L)

[0041]

Embodiment 2

[0043] (1) Before dialysis:

[0044] Normal saline side: 5L normal saline, add paricalcitol active vitamin D0.15g;

[0045] Dialysate side: the formula of the dialysis concentrate is selected from the formula of Example 1 in Table 4, wherein the selected pH regulator is citric acid; and after dilution according to A:B:water=1:1.225:32.775 Prepare hemodialysate, and the ion concentration in the hemodialysate is as shown in Table 7:

[0046] Ion concentration and pH value in dialysate after dilution in Table 7 Example 2

[0047]

[0048] (2) After dialysis

[0049]The content of paricalcitol active vitamin D in normal saline and dialysate after dialysis was detected with an automatic biochemical analyzer, and the results are shown in Table 8.

[0050] Table 8 Vitamin D content in blood and dialysate after dialysis (unit: g / 5L)

[0051]

Embodiment 3

[0053] (1) Before dialysis:

[0054] Normal saline side: 5L normal saline, add paricalcitol active vitamin D0.15g;

[0055] Dialysate side: the formula of the dialysis concentrate is selected from the formula of Example 3 in Table 4, wherein the pH regulator is citric acid, and it is prepared after dilution according to A:B:water=1:1.225:32.775 The hemodialysate, the ion concentration in the hemodialysate is shown in Table 9:

[0056] Ion concentration and pH value in dialysate after dilution in table 9 embodiment 3

[0057]

[0058] (2) After dialysis

[0059] The content of Paricalcitol active vitamin D in normal saline and dialysate after dialysis was detected with an automatic biochemical analyzer, and the results are shown in Table 10.

[0060] Table 10 Vitamin D content in blood and dialysate after dialysis (unit: g / 5L)

[0061]

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Abstract

The invention belongs to the technical field of hemodialysis concentrates, and particularly relates to a concentrate obtained by supplementing palmatol active vitamin D (C27H44O3) into a citric acid hemodialysis concentrate. The content of the paracetamol active vitamin D is 0.15 to 0.30 g / 5L. The concentrate provided by the invention can be slowly perfused in a hemodialysis manner, the content ofvitamin D in the blood of a nephrotic patient is controlled within a reasonable concentration range of a human body, loss of vitamin D in the blood is prevented, vitamin D lacked by the nephrotic patient is supplemented, minerals, bone metabolism disorder and complications of the mineral substances and the bone metabolism disorder of the chronic nephrotic patient are effectively treated, and thena higher survival rate is brought to the nephrotic patient. Meanwhile, compared with oral vitamin D capsules and intravenous injection of vitamin D, the vitamin D is added into the citric acid hemodialysis concentrate and hemodialysis is carried out, so that the preparation method is an optimal way for treating mineral substances, bone metabolic disorders and complications thereof of patients with chronic kidney diseases at present.

Description

technical field [0001] The invention belongs to the technical field of hemodialysis concentrates, in particular to a citric acid hemodialysis concentrate supplemented with vitamin D. Background technique [0002] Hemodialysis uses artificial methods to imitate the filtering function of the human kidney. Under the condition of extracorporeal circulation, it removes excess nitrogen-containing compounds, metabolic products or excess drugs and other toxic substances in the human blood, and adjusts the balance of water and electrolytes. Healing function. [0003] In my country, due to the limited source of kidney transplant donors, dialysis is the main way of life maintenance and long-term treatment for patients with end-stage renal disease. [0004] In the existing dialysis treatment technology, the hemodialysate is the liquid that needs to be used for solute exchange with the blood on both sides of the dialysis membrane through diffusion during hemodialysis. It can be directly...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K33/06A61P7/08A61K31/592A61K31/194
CPCA61K31/194A61K31/592A61K33/06A61K33/14A61P7/08A61K2300/00
Inventor 董莉莉练成
Owner 甘肃锦东医疗器械有限公司
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