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Medical composite dressing for wound repair and preparation method thereof

A wound repair and intermediate layer technology, applied in the field of medical materials, can solve problems such as unfavorable wound healing, poor mechanical properties, and single function, and achieve the effects of promoting wound healing, high porosity, and reducing diffusion area.

Active Publication Date: 2020-08-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: there are few dressings with multi-layer structure prepared by electrospinning at present, and the mechanical properties of existing medical dressings are poor, and the use of non-medicinal crosslinking agents (such as glutaraldehyde, etc.) is not conducive to wound healing. Problems such as single function

Method used

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  • Medical composite dressing for wound repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 1 As shown, this embodiment provides a composite dressing for medical wound repair. The dressing has three layers: inner, middle and outer layers: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / sodium oxidized alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is a sodium alginate / polyvinyl alcohol / sodium carboxymethyl cellulose nanofiber membrane prepared by cutting and freeze-drying aerogel moisture absorption layer; the outer layer 3 is a non-woven breathable layer , The inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue and cut into the same shape and size to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structure dressing is 0.1mm, the thickness of the middle layer is 1mm, and the thickness of the outer layer is 1mm.

[0033] The preparation method is as follows:

[0034] Step 1. Preparation of...

Embodiment 2

[0045] Such as figure 1 As shown, this embodiment provides a composite dressing for medical wound repair. The dressing has three layers: inner, middle and outer layers: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / sodium oxidized alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is a sodium alginate / polyvinyl alcohol / sodium carboxymethyl cellulose nanofiber membrane prepared by cutting and freeze-drying aerogel moisture absorption layer; the outer layer 3 is a non-woven breathable layer , The inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue and cut into the same shape and size to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structure dressing is 0.2mm, the thickness of the middle layer is 2mm, and the thickness of the outer layer is 1mm.

[0046] The preparation method is as follows:

[0047] Step 1. Preparation of...

Embodiment 3

[0058] Such as figure 1 As shown, this embodiment provides a composite dressing for medical wound repair. The dressing has three layers: inner, middle and outer layers: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / sodium oxidized alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is a sodium alginate / polyvinyl alcohol / sodium carboxymethyl cellulose nanofiber membrane prepared by cutting and freeze-drying aerogel moisture absorption layer; the outer layer 3 is a non-woven breathable layer , The inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue and cut into the same shape and size to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structure dressing is 0.3mm, the thickness of the middle layer is 3mm, and the thickness of the outer layer is 1mm.

[0059] The preparation method is as follows:

[0060] Step 1. Preparation of...

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Abstract

The invention discloses a medical composite dressing for wound repair. The dressing comprises an inner layer which is in contact with a wound, a middle layer and an outer layer. The dressing is characterized in that: the inner layer is a chitosan / polyvinyl alcohol / oxidized sodium alginate blended nano-fiber antibacterial layer; the middle layer is an aerogel moisture absorption layer prepared by subjecting a sodium alginate / polyvinyl alcohol / sodium carboxymethyl cellulose nanofiber membrane to shearing and freeze-drying treatment; and the outer layer is a non-woven fabric breathable layer, andthe inner layer, the middle layer and the outer layer are compounded through medical glue. According to the composite dressing, the mechanical property of the dressing is improved by utilizing an electrostatic spinning technology. Meanwhile, the nanofiber membrane prepared according to the electrostatic spinning technology and the nanofiber membrane aerogel obtained through aftertreatment have high porosity and large surface area, the excellent breathability can be achieved while the high moisture absorption and moisture retention performance is guaranteed, exudate diffusion is reduced, the skin is kept clean, and the dressing can be widely applied to recovery treatment of various wounds.

Description

Technical field [0001] The invention relates to a preparation method of a composite dressing for medical wound repair, belonging to the field of medical materials. Background technique [0002] The formation of wounds is mainly due to damage to the surface of the skin and mucous membranes or destruction of the integrity of organs and tissues. The healing process is complicated, and the wound is getting better slowly. It is necessary to cover the surface of the wound with a medical dressing and change it regularly to speed up the healing of the wound and prevent bacterial and dust infection. Traditional medical dressings, such as absorbent cotton yarn, can absorb moisture and protect the skin to a certain extent. However, after moisture absorption, it is easy to cause the dressing to harden, adhere to damaged tissues, and increase friction on the wound surface. At the same time, it is easy to cause secondary damage to the skin when the dressing is changed, and the antibacterial a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/42B32B5/02B32B5/26B32B7/12D01D5/00D04H1/4382D04H1/728D04H3/005D04H3/02
CPCA61L15/24A61L15/28A61L15/42B32B5/02B32B5/26B32B7/12D01D5/003D04H1/4382D04H1/728D04H3/005D04H3/02C08L5/08C08L5/04C08L29/04C08L1/286
Inventor 张佩华孙玮郭虹高原付少举
Owner DONGHUA UNIV
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