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Biomarker for vascular calcification and application thereof

A biomarker and vascular calcification technology, applied in biological testing, biomaterial analysis, material inspection products, etc., can solve the problems of radiation exposure and disadvantages of patients, and achieve the convenience of refined management, early intervention and avoidance of radiation exposure Effect

Pending Publication Date: 2020-08-11
SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the detection of vascular calcification mainly uses imaging methods, including X-ray films of the pelvis and both hands and coronary artery CT, etc., but the radiation exposure of the patient is not conducive to monitoring through repeated inspections

Method used

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  • Biomarker for vascular calcification and application thereof
  • Biomarker for vascular calcification and application thereof
  • Biomarker for vascular calcification and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The serum SMARC4 concentrations of control subjects with normal renal function (12 samples) and chronic hemodialysis patients (28 samples) were determined. All chronic hemodialysis patients were confirmed by dual-source CT examination with a coronary artery calcium score (CAC score) ≥ 30 points, which met the diagnostic criteria for chronic kidney disease (CKD)-related vascular calcification. The results are shown in Table 1 below:

[0037] Table 1

[0038]

[0039]

[0040] Note: HD: hemodialysis group

[0041] After calculation, the average serum SMARC4 concentration of subjects in the normal control group was 94.0 ± 41.6pg / ml, and the average serum SMARC4 concentration of patients in the hemodialysis group was 191.1 ± 43.2pg / ml, and there was a significant difference between the two (independent sample t test, p<0.001).

[0042] ROC curve analysis showed that the sensitivity of serum SMARC4 concentration>135.2pg / ml to predict CKD-related vascular calcificati...

Embodiment 2

[0059] The present embodiment provides a method for diagnosis or auxiliary diagnosis of vascular calcification in patients with chronic kidney disease, which includes the following steps:

[0060] (1) Detection of serum marker levels in patients with chronic kidney disease: SMARCA4 protein;

[0061] (2) compare the detection value with the reference value, the reference value is 135.2pg / ml;

[0062] (3) Result judgment:

[0063] If the detected value is higher than or equal to the reference value, it is judged that the patient has a high risk of chronic kidney disease-related vascular calcification in the future or has already suffered from severe chronic kidney disease-related vascular calcification, and needs to be closely monitored; when the detected value is lower than the reference value, it is judged that the patient Patients are at low risk of developing CKD-related vascular calcification in the future or do not yet have severe CKD-related vascular calcification.

[0...

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Abstract

The invention discloses a biomarker for vascular calcification and application of the biomarker, and relates to the field of biomedicine. The biomarker for vascular calcification is SMARCA4 protein. According to the invention, the SMARC4 protein is used as the biomarker for vascular calcification, is used for early diagnosis or auxiliary diagnosis of vascular calcification, has good sensitivity and specificity, and provides a simple and convenient detection means for early diagnosis or auxiliary diagnosis of vascular calcification.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to biomarkers of vascular calcification and applications thereof. Background technique [0002] Vascular calcification, the inappropriate pathological deposition of minerals in vascular tissue, is a common complication of chronic kidney disease (CKD) and the most important cause of cardiovascular death in patients with end-stage renal disease (ESRD). [0003] However, due to the lack of effective early biomarkers for the occurrence and development of vascular calcification, most patients with vascular calcification are already in an irreversible stage when they are diagnosed by imaging methods. The 2017 new version of KDIGO Chronic Kidney Disease-Mineral and Bone Metabolism Disease Guidelines emphasizes the importance of early detection and intervention of vascular calcification. Therefore, finding early biomarkers that can represent vascular calcification to monitor the progress...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/32
Inventor 冯韵霖李怡
Owner SICHUAN PROVINCIAL PEOPLES HOSPITAL
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