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Application of compound to preparation of medicament for treating acute lung injury

A technology for acute lung injury and compounds, applied in the field of medicine, can solve the problems of incomplete elucidation of the pathological mechanism, inability to fundamentally treat acute lung injury, and high mortality

Inactive Publication Date: 2020-08-11
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The etiology of acute lung injury is complex, its pathological mechanism has not been fully elucidated, and the mortality rate is high
At present, the treatment of acute lung injury mainly adopts high-dose corticosteroid pulse therapy, but there is a lack of convincing experimental evidence. A large number of clinical studies have confirmed that glucocorticoids can neither prevent the occurrence of acute lung injury nor have an effect on early acute lung injury. Therapeutic effect
The current drug treatment for acute lung injury is not effective, and there is a problem of treating the symptoms but not the root cause, and cannot fundamentally treat acute lung injury

Method used

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  • Application of compound to preparation of medicament for treating acute lung injury
  • Application of compound to preparation of medicament for treating acute lung injury
  • Application of compound to preparation of medicament for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The therapeutic effect of embodiment 1 LH031 on acute lung injury

[0043] (1) Modeling and administration

[0044] Seventy-two SPF male SD rats, weighing 220-250g, were anesthetized, and the necks of the rats were disinfected with iodine, and a longitudinal incision of about 1 cm was made at the midline position of the middle and lower third of the neck to expose the lower edge of the thyroid gland and turn it up Carefully separate and expose the anterior muscle group of the trachea, sharply separate the muscle group longitudinally to expose the trachea, place the animal obliquely with the head high and the bottom of the feet, insert a 1mL syringe (26G) into the trachea at about two tracheal rings under the cricoid cartilage ring, and push 2mg / kg lipopolysaccharide (LPS) solution, the administration volume is 0.8mL / kg, observe that there are no air bubbles in the nose, and immediately rotate the rat upright for 20 seconds after pushing it in, so as to ensure that the ...

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Abstract

The invention discloses application of a compound to preparation of a medicament for treating the acute lung injury. The compound disclosed by the invention can effectively reduce a death rate causedby the acute lung injury and recover the normal lung function, and a treatment effect of the compound is equivalent to that of dexamethasone acetate; and in addition, the compound can be orally taken,is more convenient to use and has important medical prospect and economic value.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a compound in the preparation of medicine for treating acute lung injury. Background technique [0002] Acute lung injury can be divided into intrapulmonary factors (direct injury) and extrapulmonary factors (indirect injury) according to whether it is primary in the lungs. It is manifested by the release of inflammatory factors, resulting in pulmonary capillary damage and increased alveolar and capillary permeability. , resulting in diffuse pulmonary interstitial and alveolar edema, thereby affecting oxygenation and causing dyspnea in patients. The pathophysiological features are reduced lung volume, decreased lung compliance, and imbalance of ventilation / perfusion flow ratio, clinically manifested as progressive hypoxemia and respiratory distress, and lung imaging manifested as heterogeneous exudative lesions . [0003] The etiology of acute lung injury is complex, its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P11/00
CPCA61K31/437A61P11/00
Inventor 许元生苏博雅张时群
Owner LINK HEALTH GRP
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