A kind of nano calcium carbonate Pickering emulsion loaded with vitamin D3 and its preparation method and application

A technology of nano-calcium carbonate and Pickering emulsion, which is applied in the fields of food and medicine, can solve problems such as discounting the emulsification performance of nano-calcium carbonate, limiting the application of modified nano-calcium carbonate, and the toxicity of chemical modifiers, so as to improve bioavailability, Reduces the burden on the gastrointestinal tract and has good stability

Active Publication Date: 2022-03-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, "bare" nano calcium carbonate particles are easy to agglomerate during the synthesis process, and the formation of agglomerates leads to a great reduction in the emulsifying properties of nano calcium carbonate
Although surface modification strategies can slow down particle aggregation during synthesis, many chemical modifiers are toxic, which limits the application of modified nano-calcium carbonate in food, medicine, and biomedicine

Method used

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  • A kind of nano calcium carbonate Pickering emulsion loaded with vitamin D3 and its preparation method and application
  • A kind of nano calcium carbonate Pickering emulsion loaded with vitamin D3 and its preparation method and application
  • A kind of nano calcium carbonate Pickering emulsion loaded with vitamin D3 and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1. Ingredients

[0064] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 50 mg / mL, and set aside;

[0065] 2. High static pressure dispersion

[0066] The nano-calcium carbonate suspension in step 1 is placed in a high static pressure device, and the working pressure is maintained for 20 min under the condition of 300 MPa to obtain a nano-calcium carbonate dispersion;

[0067] 3. Vitamin D3 oil solution

[0068] Vitamin D3 oil solution: take food-grade vitamin D3, add it to medium-chain fatty acid solution, stir for 1 hour at room temperature, away from light, at a stirring speed of 200rpm, to completely dissolve vitamin D3, and prepare a 100 IU / mL vitamin D3 oil solution for later use ;

[0069] 4. Preparation of Pickering emulsion

[0070] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a...

Embodiment 2

[0087] 1. Ingredients

[0088] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 40 mg / mL, and set aside;

[0089] 2. High static pressure dispersion

[0090] With the nano-calcium carbonate suspension in step 1 in the high static pressure equipment, it is kept 30 min under the condition of 250 MPa at working pressure, obtains the nano-calcium carbonate dispersion;

[0091] 3. Vitamin D3 oil solution

[0092] Vitamin D3 oil solution: take food-grade vitamin D3, add it to corn oil, stir at room temperature for 2 h in the dark, at a stirring speed of 300 rpm, to completely dissolve vitamin D3, and prepare a 200 IU / mL vitamin D3 oil solution for later use;

[0093] 4. Preparation of Pickering emulsion

[0094] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a volume ratio of 2:8, high-speed shear homog...

Embodiment 3

[0100] 1. Ingredients

[0101] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 20 mg / mL, and set aside;

[0102] 2. High static pressure dispersion

[0103] The nano-calcium carbonate suspension in step 1 is kept in a high static pressure device for 30 min at a working pressure of 400 MPa;

[0104] 3. Vitamin D3 oil solution

[0105] Vitamin D3 oil solution: Take food-grade vitamin D3, add it to soybean oil, stir for 3 hours at room temperature, away from light, at a stirring speed of 400rpm, to completely dissolve vitamin D3, and prepare a 50 IU / mL vitamin D3 oil solution for later use;

[0106] 4. Preparation of Pickering emulsion

[0107] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a volume ratio of 3:7, and homogenize at high speed for 14 min at a shear rate of 10,000 rpm to obtain nano-ca...

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Abstract

The invention discloses a vitamin D3-loaded nano calcium carbonate Pickering emulsion and a preparation method and application thereof, belonging to the technical fields of food and medicine. A preparation method of nano calcium carbonate Pickering emulsion loaded with vitamin D3, comprising the following steps: (1) preparing nano calcium carbonate suspension; (2) high static pressure treatment: subjecting nano calcium carbonate suspension to high static pressure Pressing to obtain nano calcium carbonate dispersion; (3) mixing vitamin D3 with edible oil, stirring under dark conditions to obtain vitamin D3 oil solution; (4) mixing above-mentioned nano calcium carbonate dispersion with vitamin D3 oil solution, Homogenized by shearing. The present invention disperses through high static pressure treatment, which can significantly reduce the agglomeration degree of nano calcium carbonate and improve the dispersibility of nano calcium carbonate particles, so that the finally prepared vitamin D3-loaded nano calcium carbonate Pickering emulsion has Good stability, viscoelasticity and bioresponsiveness.

Description

technical field [0001] The invention belongs to the technical fields of food and medicine, and in particular relates to a vitamin D3-loaded nano-calcium carbonate Pickering emulsion and a preparation method and application thereof. Background technique [0002] Pickering (Pickering) emulsion is a kind of emulsion stabilized by nano / micro-sized solid particles, which has the characteristics of good stability, anti-aggregation, anti-flocculation and anti-austenification maturation, etc. It has great potential in food, cosmetics, medicine and other fields Wide range of applications. As a drug embedding and delivery carrier, Pickering emulsion can improve the stability of loaded drugs. The types of emulsifiers and oils are the basis of the functional design of Pickering emulsions: (1) The physical and chemical structure, biocompatibility, and digestion characteristics of the granular emulsifier are the key to determine the use, structure and performance of Pickering emulsions ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/44A61K33/06A61P3/14A61K8/06A61K8/19A61K8/67A23L33/155A23L33/16A61K31/593
CPCA61K9/107A61K47/44A61K31/593A61K33/06A61P3/14A61K8/062A61K8/19A61K8/67A23L33/155A23L33/16A23V2002/00A23V2250/1578A23V2250/1576A23V2250/7106A61K2300/00
Inventor 陈填烽郭晓明李晓玲
Owner JINAN UNIVERSITY
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