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A kind of graphene mixed filler and its preparation method and graphene mixed filler chromatography column and application

A technology of mixing fillers and chromatographic columns, applied in the field of analytical chemistry, can solve the problems of inconvenient separation and elution of target compounds, and prone to agglomeration.

Active Publication Date: 2022-01-21
福州奥尼多生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since graphene also has a strong surface energy, it is prone to agglomeration itself, which brings inconvenience to the separation and elution of the target. It requires a reasonable eluent to form a chromatographic column with tangential flow combined with the space constraints of the medium material. Reasonable medium ratio and spatial dispersion can improve the effect of chromatographic separation

Method used

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  • A kind of graphene mixed filler and its preparation method and graphene mixed filler chromatography column and application
  • A kind of graphene mixed filler and its preparation method and graphene mixed filler chromatography column and application
  • A kind of graphene mixed filler and its preparation method and graphene mixed filler chromatography column and application

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Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of graphene mixed alumina chromatography column

[0028] 25 parts by weight of the graphene powder with a particle size of 3000-5000 mesh are added with water and stirred evenly to make a graphene suspension;

[0029] Adding 100 parts by weight of the graphene suspension to alumina with a particle size of 200-500 meshes, mixing evenly, and drying at 90° C. for 2-5 hours to obtain a graphene mixed medium filler;

[0030] The lower part of the chromatographic column is filled with alumina with a particle size of 200-500 mesh, the height of the lower part of the chromatographic column accounts for 8% of the height of the chromatographic column, and the upper part of the chromatographic column is filled with graphene mixed media filler, the chromatographic column The ratio of diameter to height is 1:15.

Embodiment 2

[0031] Embodiment 2: the preparation of graphene mixed silica gel chromatography column

[0032] 10 parts by weight of graphene with a particle size of 1000-3000 mesh and a concentration of 50 wt% ethanol aqueous solution are stirred evenly to make a graphene suspension;

[0033] Add 100 parts by weight of the graphene suspension to chromatographic silica gel with a particle size of 200-500 mesh, mix well and then dry at 100°C for 2-5 hours to obtain a graphene mixed media filler; graphene can form a rigid silica gel medium The cage frame immobilizes itself.

[0034]The lower part of the chromatographic column is filled with a particle size of 200-500 mesh chromatographic silica gel, the height of the lower part of the chromatographic column accounts for 5% of the height of the chromatographic column, and the upper part of the chromatographic column is filled with a graphene mixed media filler, the chromatographic column The ratio of diameter to height is 1:25.

Embodiment 3

[0035] Embodiment 3 The preparation of graphene mixed octadecyl bonded silica gel chromatography column:

[0036] 30 parts by weight of graphene powder with a particle size of 3000-5000 mesh is added to 100 parts by weight of octadecyl bonded silica gel with a particle size of 200-500 mesh and mixed uniformly to obtain a graphene mixed medium filler;

[0037] The lower part of the chromatographic column is filled with octadecyl bonded silica gel, the height of the lower part of the chromatographic column accounts for 8% of the height of the chromatographic column, and the upper part of the chromatographic column is filled with graphene mixed medium filler, the diameter of the chromatographic column The height ratio is 1:15.

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Abstract

The inventor provides a graphene mixed filler and a chromatographic column, wherein the mixed filler includes a graphene material and a chromatographic medium filler, and the weight ratio of the graphene material to the chromatographic medium filler is 1-50 : 100, the particle size of the graphene material is 500-5000 mesh, and the particle size of the chromatography medium filler is 200-500 mesh. Use the special properties of graphene (π-π electron conjugation effect) to achieve column adsorption of compounds with π-conjugated electronic structures. At the same time, the lower column has the effect of separating conventional impurities, which can be further separated and purified to absorb impurities and avoid Multiple operations are performed, which can effectively reduce the chromatography cost and operation time of the target product.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to a graphene mixed filler and a preparation method thereof, a graphene mixed filler chromatographic column and an application thereof. Background technique [0002] At present, in the field of drug production and analysis and purification, especially some drugs derived from fermentation products, many by-products with similar structures and similar physical and chemical properties are also produced during the production and fermentation process; the main products and by-products are only The difference lies in whether there is an alkene or alkyne structure; such as Lipstatin, Tacrolimus, Astaxanthin, DHA, EPA, Rapamycin, Solanesol, Coenzyme Q10, phytosterols, vitamin E, etc., the separation of the above drugs or their fermentation by-products is usually used The main product is separated and chromatographically separated by silver nitrate or macroporous adsorption resin, but in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/08C07D498/18
CPCB01D15/08C07D498/18
Inventor 乐占线乐景青秦建萍林丛王祥开
Owner 福州奥尼多生物科技有限公司
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