Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of vitamin D in prevention and treatment of intestinal injury caused by radiation

A vitamin and intestinal injury technology, applied in the field of biomedicine, can solve the problems of difficult treatment, non-specific treatment methods, complex mechanism of radiation intestinal injury, etc., and achieve outstanding effects of intestinal tissue damage

Pending Publication Date: 2020-07-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The mechanism of radiation intestinal injury is very complex, involving cell death, stem cell injury, immune activation, neuroregulatory disorder, microcirculation disorder, etc., so it is very difficult to treat clinically, and there is no specific treatment method yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of vitamin D in prevention and treatment of intestinal injury caused by radiation
  • Application of vitamin D in prevention and treatment of intestinal injury caused by radiation
  • Application of vitamin D in prevention and treatment of intestinal injury caused by radiation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0025] Experimental example 1 short-term effect

[0026] Mice: Male wild-type C57 BL / 6 mice (6-8 weeks) were purchased from the Chinese Academy of Sciences (Shanghai). All mice were raised in the SPF laboratory of the Animal Experiment Center of the Second Military Medical University of the Chinese People's Liberation Army (Shanghai). The mice were randomly divided into four groups. The control group was given a single intraperitoneal injection of 2μg / kg of phosphate buffered saline solution per day for 3 days before irradiation, followed by 7Gy of whole body irradiation at a dose rate of 1Gy / min; The group was given a single intraperitoneal injection of 2μg / kg of 1,25-(OH)2-VitD daily to mice 3 days before irradiation 3 , And then given 7Gy whole body irradiation with a dose rate of 1Gy / min; the administration control group was also given a single intraperitoneal injection of 2μg / kg of 1,25-(OH)2-VitD every day for 3 days before irradiation 3 , But not irradiated; the blank cont...

experiment example 2

[0037] Experimental example 2 long-term effect

[0038] The specific method is: feeding the mice with deficient and high vitamin D feed, and testing after 1 month. Experimental grouping: male BALB / c mice aged 6-8 weeks were selected and divided into control group, high vitamin D group, and vitamin D deficiency group according to a completely random method. The control group was fed with AIN93G standard feed, the high-vitamin D group was fed with 20000IU of high-vitamin D feed, and the vitamin D-deficient group was fed with AIN93G vitamin D-deficient feed. The mice in each group were fed relevant feed for 3 months. All mice were kept in a standardized animal room with sufficient water, 12h circadian rhythm, and a temperature of 22-25°C.

[0039] Image 6 Photomicrographs of mouse intestinal villi and crypts; Image 6 As shown, high vitamin D reduced the radiation intestinal injury in mice, while the intestinal injury in vitamin D-deficient mice was aggravated: the mice were fed a ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of biomedicine, in particular to application of vitamin D in preparation of an anti-radiation drug. The application has the beneficial effects that the new anti-radiation application of the vitamin D is found and verified for the first time, and the vitamin D can significantly prolong the lifetime of a mouse after radiation and has outstanding effects of resisting intestinal tissue injury caused by radiation.

Description

Technical field [0001] The invention relates to the field of biomedicine, in particular to the use of vitamin D in anti-radiation therapy. Background technique [0002] With the extensive development and utilization of nuclear energy in my country and the rapid development of nuclear medicine, the opportunities for people to be exposed to ionizing radiation are increasing. The 2011 Fukushima nuclear power plant accident and the recent North Korean nuclear crisis once again reminded us that the nuclear threat still exists. Radiation intestinal injury is the main cause of early death of the wounded in nuclear and radiation emergencies; it is also a common complication after radiotherapy for patients with pelvic, abdominal, or retroperitoneal tumors. At present, there is still no ideal treatment method at home and abroad. Once it occurs, the mortality rate is almost 100%. Therefore, research on the prevention and treatment of radiation-induced intestinal injury is of great signifi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61K31/59A61P17/16A61P1/00
CPCA61K31/593A61K31/59A61P17/16A61P1/00
Inventor 刘虎夏鹏林刘入菱刘婷婷杨亚杰徐唯傑乔苏迟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com