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Application of diosmetin in preparation of medicament for treating inflammatory bowel disease

A technology of inflammatory bowel disease and diosmin, which is applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of inflammatory bowel disease and the unreported effect of intestinal flora, and achieve the alleviation or improvement of ulcerative Enteritis disease, good application prospect, no adverse effect

Inactive Publication Date: 2020-07-07
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the effect of diosmin on inflammatory bowel disease and intestinal flora.

Method used

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  • Application of diosmetin in preparation of medicament for treating inflammatory bowel disease
  • Application of diosmetin in preparation of medicament for treating inflammatory bowel disease
  • Application of diosmetin in preparation of medicament for treating inflammatory bowel disease

Examples

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Effect test

Embodiment 1

[0033] Effects of nintedanib on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice

[0034] Chronic ulcerative colitis animal model preparation: 3% DSS was used to induce the chronic phase model of ulcerative colitis. During the adaptation period, the mice were allowed to eat and drink freely. After the initial adaptation period, the water was replaced with 3% (W / V ) of DSS (except the normal control group). The daily water intake of each mouse was calculated as 6 mL, and the DSS solution was supplemented to the daily water intake the next day, and the DSS solution was given for 7 days in total. After 7 days of administration, it was found that the mice had soft stools, diarrhea or bloody stools, and the mice were administered intragastrically. The mice in the normal control group and the model control group were given an equal volume of sodium carboxymethyl cellulose every day, and the mice in the positive control group Sulfasalazine 200 mg / kg was given daily, a...

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Abstract

The invention provides application of diosmetin in preparation of a medicament for treating inflammatory bowel disease (IBD), and belongs to the technical field of medicines. The diosmetin has a structure shown in the following formula (I): The diosmetin has a good effect on IBD, has no adverse reaction, can slow down ulcerative enteritis of mice induced by dextran sodium sulfate (DSS), and provides a good application prospect for treating, alleviating or improving IBD.

Description

technical field [0001] The invention belongs to the new application of diosmin, in particular, relates to the application of diosin in medicine for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBDs) is a chronic relapsing inflammatory disease of the gastrointestinal tract, mainly including Crohn's disease (Crohn's disease, CD) and ulcerative colitis (Ulcerative colitis, UC). Among them, UC is a chronic inflammatory disease affecting the colon and rectum, and its incidence has been increasing year by year in my country in recent years. Its main clinical symptoms are bloody diarrhea, abdominal pain, blood in the stool, and weight loss, which can seriously affect organs such as the liver, skin, and vision, and is accompanied by complications such as intestinal perforation, hemorrhage, toxic colon expansion, and even cancer, which seriously endanger people's lives and health. However, its pathogenesis is still unclear, and it is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/00A61P1/04
CPCA61K31/352A61P1/00A61P1/04
Inventor 杨诚周红刚李霄鹤李海龙卫怡颖张杉杉阮灏刘蕊
Owner NANKAI UNIV
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