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Bionic skin chip for medicine testing

A chip and skin technology, applied in the field of bionic skin chips for drug testing, can solve the problems of few skin chips and inability to analyze the impact, etc., and achieve the effect of increasing the drug concentration gradient, simulating the human microenvironment, and improving the detection efficiency.

Pending Publication Date: 2020-06-30
HEFEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are few skin chips in the prior art, and the skin chips in the prior art cannot analyze the influence of different concentrations of drugs on skin tissue

Method used

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  • Bionic skin chip for medicine testing
  • Bionic skin chip for medicine testing
  • Bionic skin chip for medicine testing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A bionic skin chip for drug testing, such as figure 1 with figure 2 As shown, it includes an upper chip 11, a middle chip 21, a porous membrane 31 and a lower chip 41 arranged in sequence from top to bottom. Corresponding threaded holes are provided on the surface, and the upper chip 11 , the middle chip 21 and the lower chip 41 are connected by screws.

[0050] Such as figure 2 , image 3 with Figure 4 As shown, the bottom surface of the upper chip 11 is provided with an upwardly recessed gas channel. The gas channel includes a first gas channel 12 and a second gas channel 13. The first gas channel 12 is distributed in a tree shape. In this embodiment, the first gas channel 12 is The three-level tree-like channel, the end of the three-level tree-like channel is composed of four branch channels, the number of the second gas channel 13 is four, and the four branch channels at the end of the three-level tree-like channel are connected with the four second gas chann...

Embodiment 2

[0070] H2 o 2 For the damage of skin cells, put the prepared skin tissue into the channel 22, and feed H2 with a concentration of 0% and 0.2% from the entrance of the second channel 49 respectively. 2 o 2 , after 24 hours of drug treatment, the cell viability in the cell culture chamber was detected ( Figure 7 ), the result shows that H 2 o 2 A stable concentration gradient was formed, and cell viability decreased with increasing drug concentration.

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Abstract

The invention discloses a bionic skin chip for medicine testing, and relates to the technical field of organ chips. The bionic skin chip comprises an upper-layer chip, a middle-layer chip, a porous membrane and a lower-layer chip which are sequentially arranged from top to bottom, wherein a sinking gas channel is formed in the bottom surface of the upper-layer chip, and a through slot corresponding to the gas channel is formed in the middle-layer chip; at least three sinking Tesla micro-mixers are arranged on the upper surface of the lower-layer chip, and a first air inlet channel, a first main channel, a collection channel and a first outlet channel are formed in the upper surface of the lower-layer chip; and the upper surface of the porous membrane covers the lower parts of the through slots, and the lower surface of the porous membrane covers the collection channel. The bionic skin chip has the beneficial effects the bionic skin chip is capable of providing a gas-liquid culturing environment to skin, so that culturing of gas-liquid and liquid-phase skin tissues is realized, and a microenvironment of a human body can be well simulated.

Description

technical field [0001] The invention relates to the technical field of organ chips, in particular to a bionic skin chip for drug testing. Background technique [0002] The skin is the largest organ in the human body and serves as a physiological barrier around the muscles and bones to protect tissues and organs in the body. However, the skin is constantly exposed to numerous biochemical agents (eg, cosmetics, skin washes, etc.), ultraviolet rays, pathogens, environmental pollutants, and microorganisms. A rapid increase of these factors can cause various skin reactions such as skin inflammation, irritation, allergy and even skin cancer. However, animal skin differs greatly from human skin in terms of thickness, hair density, and appendages, so studies based on animal models are limited. Furthermore, with European legislation prohibiting the testing of cosmetic ingredients on animals and increasing the number of industrial chemicals that must undergo risk assessment. Theref...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/04C12M1/04
CPCC12M21/08C12M23/16C12M25/02C12M29/06
Inventor 刘婧张敏阮班锋孟伟李鹿之太光平
Owner HEFEI UNIV
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