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Combined vaccine composed of ABCYW135 group meningococcal vaccine and Japanese encephalitis vaccine

A meningococcal and combined vaccine technology, applied in the field of combined vaccines, can solve problems such as no specific drugs

Inactive Publication Date: 2020-06-16
北京成大天和生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the prevention and treatment of Japanese encephalitis virus, there is currently no specific drug, and the most mainstream method is to control the spread of JE virus through vaccines

Method used

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Examples

Experimental program
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Embodiment Construction

[0023] The present invention includes but not limited to the following examples

[0024] Preparation of Group A, Group C, Group W135, Group Y meningococcal polysaccharide conjugated vaccine stocks:

[0025] Group A meningococcal polysaccharide-conjugated vaccine stock solution: working seed batches of group A meningococcus are cultured in a fermenter liquid, and the culture is terminated at the late logarithmic growth phase or the early stationary phase. Sampling is carried out to measure the concentration of bacteria liquid, check for pure bacteria, and sterilize after passing the test. Add formaldehyde solution to the harvested culture liquid to sterilize or use appropriate methods such as heating to sterilize; centrifuge the sterilized culture liquid to collect the supernatant, add ten Hexaalkyltrimethylammonium bromide, mix thoroughly to form a precipitate; add an appropriate amount of calcium chloride solution to the centrifuged precipitate to make the final concentration...

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PUM

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Abstract

The invention provides an ABCYW135 group meningococcus / Japanese encephalitis combined vaccine, which is prepared by the following steps: respectively extracting capsular polysaccharides from A group meningococcus, C group meningococcus, W135 group meningococcus and Y group meningococcus, purifying, and combining the activated capsular polysaccharides with diphtheria CRM197 protein; using PorA protein on outer membrane vesicles of group B meningococcus; using Vero cells for culturing encephalitis B viruses, after inactivation and purification, mixing the components according to a certain proportion, and the mixture is used for preventing infection caused by ABCYW135 group meningococci and Japanese encephalitis viruses.

Description

technical field [0001] The invention relates to a combination vaccine composed of ABCYW135 meningitis vaccine and Japanese encephalitis vaccine. Specifically, the present invention relates to a stock solution of meningococcal polysaccharides of groups A, C, W135 and Y coupled with a protein carrier, and a stock solution of group B meningococcal PorA protein and Japanese encephalitis virus purified stock solution. A new combination vaccine. More specifically, the Japanese encephalitis virus involved in the present invention is subjected to Vero cell culture, harvesting, inactivation, purification and other steps to obtain the virus stock solution. The A, C, W135 and Y group meningococcal binding stock solutions involved in the present invention are purified A group, C group, W135 group, and Y group meningococcal polysaccharides respectively combined with non-toxic mutant diphtheria toxin protein CRM 197 The stock solution of the conjugate obtained by chemical coupling. Group...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/385A61K39/095A61K39/12A61P31/14A61P31/04
CPCA61K39/385A61K39/095A61K39/12A61P31/14A61P31/04A61K2039/70C12N2770/24134A61K2039/5252A61K2039/6031Y02A50/30
Inventor 孙述学姚崧源张景春陈中秋马宏初
Owner 北京成大天和生物科技有限公司
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