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Application of betulinic acid in synergistically inducing apoptosis of multidrug-resistant breast cancer cells

A technology of human breast cancer cells and betulinic acid, which is applied in the application field of betulinic acid in synergistically inducing the apoptosis of multidrug-resistant breast cancer cells, can solve the problem of unclear working concentration of breast cancer cells and the sensitivity of conventional chemotherapy drugs Insufficient, drug resistance and other issues

Pending Publication Date: 2020-06-16
SHAANXI UNIV OF SCI & TECH
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Problems solved by technology

[0004] Luminal-type human breast cancer is sensitive to hormones, insufficiently sensitive to conventional chemotherapy drugs, and prone to drug resistance
Shi Wenbo et al. reported that betulinic acid can promote the apoptosis of human breast cancer cells, but the working concentration of betulinic acid to inhibit the growth of breast cancer cells is not yet clear, and its effect on multidrug-resistant breast cancer cells has not been seen. to report

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  • Application of betulinic acid in synergistically inducing apoptosis of multidrug-resistant breast cancer cells
  • Application of betulinic acid in synergistically inducing apoptosis of multidrug-resistant breast cancer cells
  • Application of betulinic acid in synergistically inducing apoptosis of multidrug-resistant breast cancer cells

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Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0021] The present invention not only reveals the inhibitory effect of betulinic acid on multidrug-resistant breast cancer cells, but also discovers the pro-apoptotic effect of betulinic acid combined with doxorubicin and other chemotherapeutic drugs on breast cancer cells. Drug resistance inhibitors and solving the multi-drug resistance dilemma provide a practical basis.

[0022] (1) Inhibitory effect of betulinic acid on multidrug-resistant breast cancer cells

[0023] The present invention selects American Type Culture Collection (ATCC) human breast cancer reference cell line MCF-7 (purchased from Shanghai Cell Engineering Center, Chinese Academy of Sciences) as the starting cell line, and simulates the periodic administ...

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Abstract

The invention discloses an application of betulinic acid in synergistically inducing apoptosis of multidrug-resistant breast cancer cells. The betulinic acid can inhibit the growth of a multidrug-resistant breast cancer cell strain MCF-7-AR; the betulinic acid can be used as a chemotherapy sensitizer, enhances the sensitivity of MCF-7-AR to adriamycin, docetaxel and other chemotherapy drugs, promotes apoptosis of multidrug-resistant breast cancer cells, and can be used for preparing tumor inhibitors according to the characteristic of synergistically inducing apoptosis of multidrug-resistant cells.

Description

technical field [0001] The present invention relates to the application of betulinic acid, an active ingredient of traditional Chinese medicine, as a tumor suppressor and chemotherapy sensitizer, in particular to betulinic acid synergistically enhancing the sensitivity of multidrug-resistant breast cancer cells to chemotherapy drugs such as doxorubicin, and inducing cell apoptosis. effect of death. Background technique [0002] The global incidence of breast cancer has been on the rise since the late 1970s. Breast cancer has become a major public health problem in society. At present, the chemotherapy drugs for clinical treatment of breast cancer mainly include: cyclophosphamide (Cyclophosphamide e, CTX), doxorubicin (Doxorubicin, AMD), 5-fluorouracil (5-Fluorouracil, 5-Fu), docetaxel (Docetaxel, TXT) And methotrexate (Methotrexate, MTX) and so on. However, with the increase in the dose and course of chemotherapy used by patients, secondary tumor drug resistance has becom...

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Application Information

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IPC IPC(8): A61K31/56A61P35/00
CPCA61K31/56A61P35/00
Inventor 王婷程家乐问宇昕任娟张敏
Owner SHAANXI UNIV OF SCI & TECH
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