Phenformin oral liquid fingerprint spectrum detection method and fingerprint spectrum thereof

Abstract

The invention discloses a phenformin oral liquid fingerprint spectrum detection method and a fingerprint spectrum thereof, and belongs to the technical field of traditional Chinese medicine preparation fingerprint spectrum detection. The method comprises the following steps: preparing a mixed reference substance solution and preparing a test solution; determining a high performance liquid chromatography condition; establishing a standard fingerprint spectrum; detecting the quality of the phenformin oral liquid to be detected, and analyzing the quality of the phenformin oral liquid by combininga chemometrics analysis method, wherein the chemometrics analysis method comprises a clustering analysis method and a principal component analysis method. According to the established chemical pattern recognition method taking similarity evaluation, clustering analysis and principal component analysis as cores, quality analysis can be carried out on different batches of phenformin oral liquids from different emphasis perspectives, and a scientific evaluation method is provided for quality control of preparations of the phenformin oral liquids.

Description

technical field [0001] The invention belongs to the technical field of fingerprint detection of traditional Chinese medicine preparations, in particular to a fingerprint detection method of Jiangtangling oral liquid and its fingerprint. Background technique [0002] The prescription of Jiangtangling Oral Liquid is based on Huangqi Gegen Decoction in "Zhengzhihuibu" and the classic prescription Maiwei Dihuang Wan in "Shoushi Baoyuan" written by Ming Dynasty physician Gong Tingxian, and selects a variety of natural Chinese medicinal materials A traditional Chinese medicine compound preparation elaborately made with modern technology. It has the effects of nourishing qi and nourishing yin, promoting body fluid and quenching thirst, clearing away heat and purging fire, benefiting kidney and reducing urination. It is clinically used for lowering blood sugar and treating diabetes. More than 50 years of clinical application have proved that its prescription composition and good cu...

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a Jiangtangling oral liquid fingerprint detection method and its fingerprint, which overcomes the deficiencies in the existing Jiangtangling oral liquid quality control technology, makes its quality control more perfect and scientific, and achieves the control of Jiangtangling oral liquid. Quality and then monitor the purpose of drug safety production

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