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A conductive photothermal self-healing composite hydrogel dressing and its preparation method and application

A composite hydrogel, self-healing technology, applied in the direction of drug combination, pharmaceutical formula, wave energy or particle radiation treatment materials, etc., can solve the problems of limited healing and antibacterial ability, poor treatment effect of infected wounds, etc., to achieve Excellent photothermal antibacterial performance, independent and effective self-repair ability, remarkable effect

Active Publication Date: 2021-12-07
THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the antibacterial activity and self-healing of the hydrogel are the inherent properties of the raw material itself. Although the healing and antibacterial capabilities are significant but limited, and the treatment effect on infected wounds is not good, therefore, there is an urgent need for a hydrogel that can be used on full-thickness skin. Bactericidal, antibacterial, self-healing and better healing dressings in wound infection models

Method used

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  • A conductive photothermal self-healing composite hydrogel dressing and its preparation method and application
  • A conductive photothermal self-healing composite hydrogel dressing and its preparation method and application
  • A conductive photothermal self-healing composite hydrogel dressing and its preparation method and application

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preparation example Construction

[0069] The present invention provides a method for preparing a conductive photothermal self-healing composite hydrogel dressing, comprising the steps of:

[0070] S1: Preparation of N- carboxyethyl chitosan polymers: 1) to give chitosan chitosan dispersion was suspended in deionized water, followed by continuous stirring acrylic acid was added dropwise, with stirring at a temperature of 30-80 deg.] C 24-96 hours to obtain a reaction solution; 2) aqueous sodium hydroxide was added to the reaction solution, the reaction solution was adjusted to pH 8-12, then the reaction solution was dialyzed against distilled water, was repeated changing the water 3-5 days, and then freeze-dried, to give N- carboxyethyl chitosan polymers; wherein a mass ratio of chitosan and acrylic acid (2-6) :( 1-8), the concentration of the chitosan dispersion was 15mg / mL ~ 25mg / mL aqueous sodium hydroxide solution at a concentration of 0.5mol / L ~ 2mol / L;

[0071] S2: aldehyde terminated Preparation of ...

Embodiment 1

[0092] S1: CEC (N-Carboxyethyl Chitosan, N-Carboxyethyl chitosan) polymer preparation: 4.0 g of chitosan in 200 ml of deionized water, stirring continuously, then 5.84 ml acrylic acid is added to In the suspension, the mixture was continued at 50 ° C for 72 hours, and after the reaction, the pH of the reaction mixture was adjusted to 8-12 with a 1 mol / L sodium hydroxide solution, and the mixture was dialyzed with distilled water (MWCO 8000), and the water was repeated for 3 days. , Then freeze and dried to give pure CEC polymers;

[0093] S2: PF127-CHO (Benzaldehyde-Terminated PF127, aldehyde-based F127) Preparation of the polymer:

[0094] 1) 25g The F127 polymer was sealed in three bottles of nitrogen gas for 30 minutes, and dried under vacuum at 80 ° C for 12 hours, then dried dichloromethane was added, and 2.772 ml of dried triethylamine was added under ice bath at 0 ° C, thoroughly stirred 10 In a minute, 1.584 ml of dried methanesulfonyl chloride was dissolved in 39.6 ml...

Embodiment 2

[0099] The aldehyde-based end of step S3 The carbon nanotube (CNTS) final concentration in the F127 / carbon nanotube dispersion was controlled at 8 mg / ml, and the other conditions were as in Example 1 to obtain CEC / PF / CNT2 hydrogel.

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Abstract

The invention provides a conductive photothermal self-healing composite hydrogel dressing, a preparation method and an application. N-carboxyethyl chitosan polymer is obtained by grafting acrylic acid on chitosan; Grafting p-hydroxybenzaldehyde on the material to obtain an aldehyde group-terminated polymer (PF127-CHO); after the aldehyde group-terminated polymer is prepared into a solution, carbon nanotubes are added to the polymer solution, and ultrasonic in an ice bath, Obtain the aldehyde group-terminated / carbon nanotube dispersion; prepare the N-carboxyethyl chitosan polymer into a solution, and mix with the aldehyde group-terminated / carbon nanotube dispersion, and cross-link each other at 20-45 ° C for 5 ~400 seconds, a nanocomposite hydrogel with electrical conductivity, adhesion, self-healing, photothermal, and nanocomposite was obtained. The present invention has excellent adhesion, self-healing, pH response, biocompatibility, hemostatic properties, and can exhibit photothermal behavior after being exposed to the near-infrared (NIR) region, causing physical damage to bacteria, and has therapeutic effects. Great potential for infected wounds.

Description

Technical field [0001] The present invention belongs to the technical field of biodegradable medical material, particularly relates to a heat conductive optical self-healing composite hydrogel dressing and preparation method and application. Background technique [0002] The body's largest organ is the skin, it is to prevent dehydration, the external environment of chemical / radiation injury and invading microorganisms first barrier. However, after suffering serious damage (including surgery, burns, skin diseases, etc.), the barrier will lose its basic protection mechanism, eventually causing a wound. Once the damaged tissue lost as a primary function of protecting the barrier, during which microorganisms easily invade the wound site and form colonies, leading to further infection and cause chronic wounds. Bacterial infections wounds will seriously affect the quality of life and even threaten the patient's life. It will also bring a heavy burden on health care systems around the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L71/02C08L5/08C08K3/04C08B37/08A61K9/06A61K31/722A61K41/00A61K47/10A61K47/36A61L26/00A61P17/02A61P31/04
CPCA61K9/06A61K31/722A61K41/0052A61K47/10A61K47/36A61L26/0004A61L26/0019A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/108A61L2300/232A61L2300/404A61P17/02A61P31/04C08B37/003C08J3/075C08J3/24C08J2371/02C08J2405/08C08K2201/001C08K2201/011C08K3/041C08L71/02C08L5/08A61K2300/00
Inventor 薛力郭保林贺佳辉
Owner THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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