A short peptide for cancer targeted therapy and its ultrasound-responsive nano drug-loaded microbubble and its application

A nano-drug loading and targeted therapy technology, which is applied in the field of biomedicine to achieve the effect of eliminating adverse consequences and protecting the ability of recognition and binding

Active Publication Date: 2022-02-01
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Currently, there is no report revealing anti-angiogenesis related reports of microbubbles / microspheres / microparticles / liposomes targeting Dll4-Notch4

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  • A short peptide for cancer targeted therapy and its ultrasound-responsive nano drug-loaded microbubble and its application
  • A short peptide for cancer targeted therapy and its ultrasound-responsive nano drug-loaded microbubble and its application
  • A short peptide for cancer targeted therapy and its ultrasound-responsive nano drug-loaded microbubble and its application

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Embodiment Construction

[0027] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention. It should be noted that the terms "comprising" and "having" and any variations thereof in the description and claims of the present invention are intended to cover non-exclusive inclusion, for example, processes, methods, A system, product or device is not necessarily limited to those steps or elements explicitly listed, but may inclu...

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Abstract

The invention discloses a short peptide used for cancer targeted therapy, ultrasound-responsive nano drug-carrying microbubbles based on the short peptide and its application, and belongs to the technical field of biomedicine. The short peptide disclosed in the present invention is a novel short peptide composed of 9 amino acids. At the same time, the present invention adopts the principle of ultrasonic irradiation combined with drug-loaded targeting microbubbles to establish a molecular targeting method for neovascularization based on the novel short peptide. Ultrasound-responsive nano drug-loaded microbubbles, carboxylated PEG termini on the surface of drug-loaded nanoparticles and NH of short peptide terminal amino acids 2 Combining to form an amide bond, the connection method of the terminal amino group reduces the impact on the conformation and activity of the novel polypeptide, and protects the recognition and binding ability of the novel polypeptide and the highly expressed Dll4 ligand on the surface of vascular endothelial cells as much as possible. Compared with the previous hD4R peptide, the combination of the active ingredients in it with nano drug delivery system and ultrasound will provide a new and efficient mode of anti-tumor angiogenesis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a short peptide for targeted therapy of cancer, an ultrasound-responsive nano drug-carrying microbubble based on the short peptide and its application. Background technique [0002] In recent years, the increasing incidence of tumors has attracted people's attention. According to statistics, 286 people suffer from cancer for every 100,000 people, and 181 of them die from cancer. On average, 3 out of 5 cancer patients die from cancer. Angiogenesis is one of the necessary conditions for the growth of solid tumors. Therefore, anti-angiogenesis therapy has become an effective strategy for molecular targeted therapy of tumors. However, current research in this field at home and abroad shows that the therapeutic targeting is relatively single and the effect is limited. Therefore, how to find a molecule or target that can target tumor angiogenesis is an urgent problem to be solved. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/705A61K47/60A61K38/17A61K41/00A61K47/62A61K47/69A61P35/00
CPCC07K14/70571A61K47/60A61K38/1787A61K41/0028A61K47/62A61K47/6925A61P35/00A61K2300/00
Inventor 张悦赵堃何光彬
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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