Collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and preparation method thereof
A technology for polyvinyl alcohol embolization microspheres and polyvinyl alcohol microspheres, which is applied in the field of clinical medical embolization treatment, can solve the problems of short half-life of glass microspheres, low specific activity of radioactivity, etc. The effect of uniform particle size distribution and smooth surface
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Embodiment 1
[0046] Such as Figure 1-Figure 6 As shown, a preparation method of collagen-polyvinyl alcohol embolization microspheres loaded with iodine 131 comprises the following steps:
[0047] 1), using polyvinyl alcohol as raw material, adopting emulsification cross-linking method to prepare polyvinyl alcohol microspheres:
[0048] 11), prepare the polyvinyl alcohol microspheres into a polyvinyl alcohol solution with a concentration of 50 mg / mL, which is solution A;
[0049] 12), add Span80 or Tween80 to liquid paraffin, 500r / min fully stirs 10min to obtain solution B, the volume ratio of described liquid paraffin and emulsifier is 25:1;
[0050]13) Heat both solution A and solution B in a water bath to 50 degrees, under stirring (500r / min), add solution A to solution B dropwise with a sample gun, the volume of solution A and solution B The ratio is 1:10, continue to react for 30 minutes in a 50-degree water bath and 500r / min magnetic stirring, and obtain a milky white solution C; ...
Embodiment 2
[0063] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:
[0064] The concentration of solution A is 10mg / mL; The volume ratio of described liquid paraffin and emulsifier is 10:1; The concentration of described collagen solution is 3.0mg / mL; The concentration of described collagen solution and polyvinyl alcohol microsphere suspension The volume ratio is 1:1.
Embodiment 3
[0066] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:
[0067] The concentration of solution A is 100mg / mL; The volume ratio of described liquid paraffin and emulsifier is 40:1; The concentration of described collagen solution is 5.0mg / mL; The concentration of described collagen solution and polyvinyl alcohol microsphere suspension The volume ratio is 5:1.
[0068] Since the properties and effects of the iodine-131-loaded collagen-polyvinyl alcohol embolic microspheres prepared in Example 1, Example 2 and Example 3 are similar, they will not be elaborated one by one. Properties and effects of embolic microspheres.
[0069] The collagen-polyvinyl alcohol embolization microspheres (131I-PVA-COL1 microspheres) loaded with iodine 131 prepared in Example 1 were tested for labeling rate, and the detection method was:
[0070] Measure the labeling rate with paper chromatography, the stationary phase is Xinhua No. I paper, and the developing agent...
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