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Traditional biological processing method of Chinese medicine decoction pieces

A technology of biological processing and Chinese medicine, which is used in pharmaceutical formulas, plant raw materials, plant/algae/fungi/moss composition, etc., which can solve problems such as decreased efficacy, more residues in medicinal materials, and achieve the effect of saving energy and removing toxicity.

Inactive Publication Date: 2020-06-05
重庆市康万佳中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the beneficial elements contained in the steamed and fried Chinese herbal pieces are reduced due to evaporation and decomposition under the action of high temperature, which reduces the efficacy of the medicine.
[0003] In addition, in large pharmaceutical factories, due to the large output of medicines and the variety of medicines, in order to continue the production of medicines, it is necessary to stock up a large amount of Chinese herbal medicines in the medicinal materials warehouse, so some Chinese herbal medicines are stored for several years. For these If the aged medicinal materials are directly processed according to the normal method of decoction pieces of traditional Chinese medicine without treatment, more toxins such as Aspergillus aflatoxin (AFB1) will remain in the processed medicinal materials
At present, there is no report on how to process the aged medicinal materials into Chinese herbal pieces

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The biological processing method of Chinese medicinal slices of the present invention comprises the following steps:

[0021] Step1) Clean system: After washing the ginseng medicinal material with clear water, put it into a 0.5% sodium hydroxide solution and soak it for 60 seconds, then add hydrochloric acid solution to the sodium hydroxide solution to adjust the pH to neutral, and let stand for 60 Seconds later, rinse with clean water to meet the purity requirements of the Pharmacopoeia;

[0022] Step 2) Cultivation of Rhodococcus: Firstly, make LB liquid medium, add 10g of tryptone, 5g of yeast extract, and 10g of NaCl to each liter of deionized water in the LB medium, then adjust the pH to 7.0 with sodium hydroxide, and heat it at 120 degrees Celsius , after 25min autoclaving; put Rhodococcus erythropolis into LB liquid medium and cultivate for 2-3 days to obtain Rhodococcus erythropolis solution;

[0023] Step3) Bioprocessing: After the medicinal material is sliced...

Embodiment 2

[0026] The biological processing method of Chinese medicinal slices of the present invention comprises the following steps:

[0027] Step1) Cleaning system: Wash Polygonum Polygoni Multiflori with clear water, soak it in 1.5% sodium hydroxide solution for 80 seconds, then add hydrochloric acid solution to the sodium hydroxide solution to adjust the pH to neutral, and let it stand for 70 seconds After that, wash it with clean water to meet the purity requirements of the Pharmacopoeia;

[0028] Step 2) Cultivation of Rhodococcus: Firstly, make LB liquid medium, add 10g of tryptone, 5g of yeast extract, and 10g of NaCl to each liter of deionized water in the LB medium, then adjust the pH to 7.0 with sodium hydroxide, and heat it at 120 degrees Celsius , after 25min high-pressure sterilization; put Rhodococcus into LB liquid medium and cultivate for 2-3 days to obtain Rhodococcus solution;

[0029] Step3) Bioprocessing: put Polygonum multiflorum multiflorum slices into the Rhodoc...

Embodiment 3

[0032] The biological processing method of Chinese medicinal slices of the present invention comprises the following steps:

[0033] Step1) net system: After the kudzu root medical material is washed with clear water, insert concentration and be after soaking in 1% sodium hydroxide solution for 70 seconds, then add hydrochloric acid solution to adjust pH to neutrality in sodium hydroxide solution, leave standstill 65 Seconds later, rinse with clean water to meet the purity requirements of the Pharmacopoeia;

[0034] Step 2) Cultivation of Rhodococcus: Firstly, make LB liquid medium, add 10g of tryptone, 5g of yeast extract, and 10g of NaCl to each liter of deionized water in the LB medium, then adjust the pH to 7.0 with sodium hydroxide, and heat it at 120 degrees Celsius , after 25min high-pressure sterilization; put Rhodococcus into LB liquid medium and cultivate for 2-3 days to obtain Rhodococcus solution;

[0035] Step3) Bioprocessing: put Pueraria root slices into the Rh...

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Abstract

The invention discloses a biological processing method of traditional Chinese medicine decoction pieces. The method includes the following steps: step 1) purified preparation for purity requirements in Pharmacopoeia; step 2) rhodococcus culture; step 3) biological processing: slicing medicinal materials, putting the sliced materials into the obtained rhodococcus solution, putting agar powder intothe obtained rhodococcus solution, performing thorough mixing so as to make the concentration of the agar powder at 12-15 g / L, and burying the sliced medicinal materials for 18-25 hours at an ambienttemperature of 27-38 DEG C; and step 4) drying. According to the biological processing method of the traditional Chinese medicine decoction pieces, a low-temperature biological processing technology is adopted so that beneficial ingredients which are contained in the traditional Chinese medicine can be reserved effectively; and in addition, since AFBI can be degraded efficiently by rhodococcus, the toxicity of the traditional Chinese medicine can be reduced significantly.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine processing, in particular to a bioprocessing method for prepared slices of traditional Chinese medicine. Background technique [0002] Chinese herbal decoction pieces are Chinese medicinal materials that have been processed according to the theory of traditional Chinese medicine and the processing methods of traditional Chinese medicine, and can be directly used in Chinese medicine clinics. General Chinese herbal decoction pieces are made by steaming and frying at high temperature. After steaming and frying, the toxicity contained in Chinese herbal decoction pieces can be reduced. However, the beneficial elements contained in the steamed and fried Chinese herbal pieces are reduced due to evaporation and decomposition under the action of high temperature, which reduces the efficacy of the medicine. [0003] In addition, in large pharmaceutical factories, due to the large outpu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/704A61K36/488
CPCA61K36/258A61K36/488A61K36/704A61K2236/13A61K2236/17A61K2236/19
Inventor 吕蛟
Owner 重庆市康万佳中药饮片有限公司
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