Nanoparticle emulsion loaded with skin nutrition agent and preparation method thereof

A nutrient and nanoparticle technology, which is applied in the field of nanoparticle emulsion preparation, can solve problems such as insufficient encapsulation rate and permeability, unfriendly environment and skin, and poor stability of nanocapsules, so as to increase emulsion stability , Increased specific surface area, good encapsulation efficiency

Active Publication Date: 2020-06-02
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese invention patent CN200680035440.4 discloses a method for producing nanocapsules and microcapsules of spider silk protein, but solvents such as guanidine thiocyanate and toluene are used, which are not very friendly to the environment and skin
And it is directly coated with macromolecular spidroin protein, the emulsifying power is not good, and the spidroin protein is not resistant to acid and alkali, the stability of the produced nanocapsules is not good, and the encapsulation efficiency and permeability are not good enough

Method used

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  • Nanoparticle emulsion loaded with skin nutrition agent and preparation method thereof
  • Nanoparticle emulsion loaded with skin nutrition agent and preparation method thereof
  • Nanoparticle emulsion loaded with skin nutrition agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] A nanoparticle emulsion loaded with skin nutrients and a preparation method thereof, characterized in that the following steps are adopted:

[0070] A. Pretreatment of spider silk: Weigh 100g of spider silk and place it in a sodium carbonate solution with a weight percentage of 0.8% at 81°C and stir at 600 r / min for 20 minutes to perform the first degumming. After the degumming is completed, pour out the solution. Take out the spider silk and wash it repeatedly with distilled water for 10 minutes, then place it in a sodium carbonate solution with a weight percentage of 0.8% and stir it at 600 r / min for 20 minutes at 81°C, perform the second degumming, put it in an oven at 90°C, and dry it. Dried spider silk fibers;

[0071] B. Weigh 50 g of the spider silk fibers obtained in step A, place them in a 30% by weight calcium chloride solution and stir at 600 r / min at 81°C until the spider silk fibers are completely dissolved to obtain a spider silk protein calcium chloride m...

Embodiment 2

[0079] A nanoparticle emulsion loaded with skin nutrients and a preparation method thereof, characterized in that the following steps are adopted:

[0080] A. Pretreatment of spider silk: Weigh 100g of spider silk and place it in a sodium carbonate solution with a weight percentage of 0.8% at 82°C and stir at 600 r / min for 20 minutes to perform the first degumming. After the degumming is completed, pour out the solution. Take out the spider silk and wash it repeatedly with distilled water for 10 minutes, then place it in a sodium carbonate solution with a weight percentage of 0.8% and stir it at 600 r / min for 20 minutes at 82°C, perform the second degumming, put it in an oven at 90°C, and dry it. Dried spider silk fibers;

[0081] B. Weigh 50 g of the spider silk fiber obtained in step A, place it in a 30% by weight calcium chloride solution and stir at 600 r / min at a speed of 82° C. until the spider silk fiber is completely dissolved to obtain a spider silk protein calcium ch...

Embodiment 3

[0089] A nanoparticle emulsion loaded with skin nutrients and a preparation method thereof, characterized in that the following steps are adopted:

[0090] A. Pretreatment of spider silk: Weigh 100g of spider silk and place it in a sodium carbonate solution with a weight percentage of 0.8% at 83°C and stir at 600 r / min for 20 minutes to perform the first degumming. After the degumming is completed, pour out the solution. Take out the spider silk and wash it repeatedly with distilled water for 10 minutes, then place it in a sodium carbonate solution with a weight percentage of 0.8% and stir it at 600 r / min for 20 minutes at 83°C, perform the second degumming, put it in an oven at 90°C, and dry it. Dried spider silk fibers;

[0091] B. Weigh 50 g of the spider silk fibers obtained in step A, place them in a 30% by weight calcium chloride solution and stir at 600 r / min at a speed of 83°C until the spider silk fibers are completely dissolved to obtain a spider silk protein calcium...

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Abstract

The invention relates to a nanoparticle emulsion loaded with a skin nutrition agent and a preparation method thereof. The nanoparticle emulsion is characterized by comprising the following ingredientsin percentage by weight: 0.1 percent to 50 percent of spider silk protein, 0.1 percent to 10 percent of bis[2-Hydroxyethyl] imino tris-(hydroxymethyl)-methane, 0.1 percent to 40 percent of the skin nutrition agent and 0.1 percent to 85 percent of a water and ethanol mixture, wherein the molecular weight of the spider silk protein is 80 to 100 kDa. The obtained nanoparticle emulsion loaded with the skin nutrition agent has higher biocompatibility, is milder, and has low irritation. Compared with other spider silk protein nanoemulsion, the nanoparticle emulsion has the advantages of higher encapsulation rate, better absorption permeability and higher stability.

Description

technical field [0001] The invention relates to the technical field of nanoparticle emulsion preparation, in particular to a nanoparticle emulsion loaded with skin nutrients and a preparation method thereof. Background technique [0002] With the development of science and technology and the improvement of people's beauty awareness, more and more beauty ingredients are used in cosmetics, but many raw materials have problems such as difficulty in dissolution and easy discoloration. As a new carrier, nano-preparation technology has been used in cosmetics, but the current nano-particle emulsions mostly use chemical surfactants, which have a certain impact on the skin barrier. [0003] Spider silk is a natural protein fiber with mechanical properties such as high strength, high elasticity, and high fracture energy, as well as biological properties such as significant degradability and tissue compatibility. It is used in biomedicine, materials, textiles, and military equipment. ...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/64A61K8/41A61K8/34A61K8/63A61K8/67A61K8/9755A61K8/35A61K8/49A61K8/9789A61K8/68A61K8/92A61Q19/00C12P21/06C07K14/435C07K1/34
CPCA61K8/06A61K8/64A61K8/41A61K8/347A61K8/63A61K8/671A61K8/9755A61K8/35A61K8/498A61K8/9789A61K8/68A61K8/922A61Q19/00C12P21/06C07K14/43518
Inventor 刘晓青李欣航毕永贤王晗宁朱士强蒋丽刚
Owner PROYA COSMETICS
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