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Preparation method of solanum nigrum extract for reducing uric acid of hyperuricemia

A technology of hyperuricemia and water extract, applied in the field of preparation of Solanum nigrum extract, can solve problems such as adverse reactions, gastrointestinal discomfort, liver and kidney function damage and the like

Inactive Publication Date: 2020-05-22
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can effectively reduce uric acid levels in the blood, they may also cause gastrointestinal discomfort, liver and kidney damage, and other adverse reactions. In rare cases, allopurinol can cause sudden liver failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Below in conjunction with example, the specific embodiment provided by the present invention is described in detail as follows:

[0012] Put nightshade dried fruit powder extract into capsules, each capsule contains 500mg of extract.

[0013] 32 patients with hyperuricemia were randomly divided into two groups. The patients in the experimental group took capsules containing 500 mg dried nightshade fruit powder, twice a day, for 10 consecutive weeks; the patients in the blank group took capsules containing placebo capsules, twice a day for 10 weeks. The uricase method was used to measure the patients on the 0th day and the 70th day after taking the capsules. The results are as follows.

[0014] Table 1 Examination of serum uric acid content in patients with hyperuricemia after administration

[0015] Measurement time Experimental group (mg / dL) Blank group (mg / dL) Baseline (Day 0 ) 8.45±1.08 8.28±0.89 70 days 5.75±0.48 7.34±0.32

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Abstract

The invention discloses a dried solanum nigrum fruit extract preparation for treating hyperuricemia and an application of the extract preparation. The herbal preparation is prepared by the steps of performing extraction on dried solanum nigrum fruits by ethanol, methanol, acetone and water and performing concentration. Human experiments verify that the herbal preparation can effectively improve the health level of patients with the hyperuricemia and reduce the content of uric acid in serum, and therefore, the herbal compound preparation has potential value for being developed into a drug or related food for treating the hyperuricemia and gout.

Description

technical field [0001] The invention belongs to the field of plant extraction, and in particular relates to a preparation method of Solanum nigrum extract for reducing uric acid in hyperuricemia. Background technique [0002] Hyperuricemia is a metabolic disease in which the content of uric acid in the blood increases due to purine metabolism disorders, and it is also the cause of gout. It has been reported that 18.8% of patients with hyperuricemia developed gout within five years. Studies have shown that hyperuricemia is not only related to gout, but also high blood uric acid can easily cause atherosclerosis, hypertension and metabolic syndrome such as obesity, hypertension, diabetes and other diseases. Excessive production of uric acid metabolism or decreased excretion will lead to increased uric acid content in the blood. At present, there are two types of drugs for the treatment of hyperuricemia. One is uric acid drugs, such as probenecid and benzbromarone. Another ty...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P19/06A61K131/00
CPCA61K36/81A61K2236/333A61K2236/53A61P19/06
Inventor 宋元达赛德侯赛因杨俊换杨武
Owner SHANDONG UNIV OF TECH
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