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Albendazole tablet and preparation method thereof

Albendazole tablets and albendazole technology are applied in the direction of pharmaceutical formulas, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., and can solve adverse reactions of poultry and livestock, glycogen depletion, insect pests, etc. The problems such as the inability of the body to survive and reproduce, etc., to achieve the effect of helping the body to expel the body and repelling the insects in a wide range

Inactive Publication Date: 2020-05-12
河南官渡生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. It can be used clinically to drive away roundworms, pinworms, tapeworms, whipworms, hookworms, and strongyloid nematodes. It is rapidly metabolized into sulfoxide, sulfone alcohol and 2 in the body. -Sumisulfone can inhibit the absorption of glucose by parasites, leading to the depletion of glycogen in parasites; it can also inhibit the fumarate reductase system and hinder the production of ATP; it can selectively and irreversibly inhibit parasite intestinal wall cells for intestinal nematodes The polymerization of the cytoplasmic microtubule system blocks its uptake and absorption of various nutrients and glucose, leading to the depletion of endogenous glycogen in the worm, and inhibiting the fumarate reductase system to prevent the production of adenosine triphosphate, resulting in the inability of the worm to survive and reproduce
[0003] In the prior art, if the albendazole preparation is used to kill insects on animals, the curative effect will be poor if the dosage is small, and if the dosage is large, it will easily cause adverse reactions in poultry and livestock due to the low toxicity of the albendazole preparation in the prior art. For example, phenomena such as fetal absorption and skeletal deformity occur, so there are often results of administration inconvenience and side effects. This reason has caused inconvenience to the use of albendazole tablets in the prior art and has limited the clinical application of the drug.

Method used

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  • Albendazole tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of preparation method of albendazole sheet, comprises the steps:

[0024] (1) Weighing: 50g of albendazole; 100g of bitter bark; 100g of betel nut; 100g of torreya; 100g of thunder pill; 80g; sodium lauryl sulfate 10g; cornstarch 20g, set aside;

[0025] (2) Pulverize the bitter bark, betel nut, torreya, thunder pill and sucrose first, and pass through an 80-mesh sieve, then mix albendazole, dextrin, sucrose powder, low-substituted hydroxypropyl cellulose, 40g carboxymethyl Sodium starch and crushed Kujianpi, betel nut, torreya and Leiwan are mixed evenly to obtain dry powder;

[0026] (3) Mix cornstarch with water and make a starch slurry with a mass fraction of 10%, then add the dry powder prepared in step (2), mix evenly, pass through a 16-mesh sieve, and then dry at 60°C for 3 hours to obtain Albendazole powder granules, after granulation, add the remaining auxiliary materials sodium carboxymethyl starch and sodium lauryl sulfate and mix for 30min, then com...

Embodiment 2

[0028] A preparation method for albendazole sheet, is characterized in that, comprises the steps:

[0029] (1) Weighing: 40g of albendazole; 60g of bark; betel nut 80g; 20g sodium lauryl sulfate; 25g cornstarch, set aside;

[0030] (2) Pulverize the bitter bark, betel nut, torreya, sucrose and Leiwan first, and pass through a 100-mesh sieve, then mix albendazole, dextrin, sucrose powder, low-substituted hydroxypropyl cellulose, 45g carboxymethyl Starch sodium and pulverized Kujianpi, betel nut, torreya and Leiwan are mixed evenly to obtain dry powder;

[0031] (3) Mix cornstarch with water and make a starch slurry with a mass fraction of 10%, then add the dry powder prepared in step (2), mix evenly, pass through a 17-mesh sieve, and then dry at 60°C for 4h until Moisture content reaches 2.5%. After granulation, add the remaining auxiliary materials sodium carboxymethyl starch and sodium lauryl sulfate and mix for 40 minutes, and then compress the albendazole granules into 1 ...

Embodiment 3

[0033] A preparation method for albendazole sheet, is characterized in that, comprises the steps:

[0034] (1) Weighing: 60g of albendazole; 110g of bark bark; 140g of betel nut; 120g of torreya; 120g of thunder pill; 30g sodium lauryl sulfate; 20g cornstarch, set aside;

[0035] (2) Pulverize Kujianpi, betel nut, torreya and Leiwan first, and pass through a 120 mesh sieve, then mix albendazole, dextrin, sucrose powder, low-substituted hydroxypropyl cellulose, 60g carboxymethyl starch Sodium and pulverized Kujianpi, betel nut, torreya and Leiwan are mixed evenly to obtain dry powder;

[0036] (3) Mix cornstarch with water and make a starch slurry with a mass fraction of 10%, then add the dry powder prepared in step (2), mix evenly, pass through a 18-mesh sieve, and then dry at 65°C for 3h until When the water content reaches 3%, albendazole granules are obtained. After granulation, add the remaining sodium carboxymethyl starch and sodium lauryl sulfate, mix for 30-50 minutes...

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Abstract

The invention relates to the technical field of drug preparations, and specifically relates to albendazole tablet and a preparation method thereof. The albendazole tablet consists of, in parts by weight, 3-6 parts of albendazole, 6-11 parts of Sichuan chinaberry bark, 8-14 parts of areca seeds, 7-12 parts of grand torreya seeds, 8.5-12 parts of omphalia, 8-13 parts of dextrin, 20-30 parts of sucrose, 4-6 parts of low-substituted hydroxypropyl cellulose, 8-12 parts of sodium carboxymethyl starch, 1-3 parts of sodium dodecyl sulfate and 2-2.5 parts of corn starch. Through the combination of traditional Chinese medicines and western medicines, the parasite-expelling capacities and parasite-expelling effects of the albendazole can be significantly enhanced; and compared with albendazole tablets in the prior art, the toxicity of the albendazole tablet can be obviously reduced, so that the albendazole tablet is safer in application.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an albendazole tablet and a preparation method thereof. Background technique [0002] Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. It can be used clinically to drive away roundworms, pinworms, tapeworms, whipworms, hookworms, and strongyloid nematodes. It is rapidly metabolized into sulfoxide, sulfone alcohol and 2 in the body. -Sumisulfone can inhibit the absorption of glucose by parasites, leading to the depletion of glycogen in parasites; it can also inhibit the fumarate reductase system and hinder the production of ATP; it can selectively and irreversibly inhibit parasite intestinal wall cells for intestinal nematodes The polymerization of the cytoplasmic microtubule system blocks its uptake and absorption of various nutrients and glucose, leading to the depletion of endogenous glycogen in the worm, and inhibiting the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P33/10A61K9/20A61K47/36A61K47/20A61K31/4184
CPCA61K9/2013A61K9/2059A61K31/4184A61K36/07A61K36/13A61K36/58A61K36/889A61P33/10A61K2300/00
Inventor 隗存珠徐超军董炎超闫虎峰陈晓利范智杰
Owner 河南官渡生物工程有限公司
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