Active-passive ultrasonic composite imaging method and system for focused ultrasonic irradiation of phase-change nano-droplets

Abstract

The invention provides an active and passive ultrasonic composite imaging method and system for focused ultrasonic irradiation on phase change nanometer liquid drops. After passive ultrasonic originalradio frequency signals are subjected to time delay compensation processing, a cross-correlation coefficient matrix and a passive amplitude coherent wave beam forming energy matrix are obtained respectively through two complementary square wave apodizing functions and an amplitude coherent coefficient; after the two matrixes are subjected to point multiplication, a high-resolution passive ultrasonic imaging result is obtained; phase change microbubble group mother wavelets are constructed through a phase change microbubble group vibration model; active wave beam forming radio frequency signals obtained after the mother wavelets are used for performing time delay superposition on the active ultrasonic original radio signals are subjected to continuous wavelet transformation to obtain a high-contrast active ultrasonic imaging result; and a composite image is obtained after the high-resolution passive and high-contrast active ultrasonic imaging results are compounded. The method and thesystem can be used for performing whole-process monitoring on cavitation activities in the focused ultrasonic irradiation process of the phase change nanometer liquid drops and the residue phase change microbubbles when the irradiation is stopped.

Description

technical field [0001] The invention belongs to the field of ultrasonic detection and ultrasonic imaging, and in particular relates to an active-passive ultrasonic composite imaging method and system for focused ultrasonic irradiation of phase-change nano-droplets. Background technique [0002] In recent years, phase-change nano-droplets have been widely used in ultrasound therapy and diagnostic imaging. Compared with ultrasound contrast agents, phase-change nano-droplets are small enough to diffuse through the space between tumor vascular endothelial cells to achieve Tumor tissue, combined with in vitro focused ultrasound irradiation, can achieve the purpose of ultrasonic targeted therapy for tumors; in addition, phase-change nano-droplets have high stability and can exist in the blood circulation for a long time. [0003] The safety of focused ultrasound combined with phase-change nano-droplet therapy depends on the development of monitoring imaging technology, that is, th...

AI Technical Summary

Problems solved by technology

At present, the most commonly used B-mode ultrasound imaging method is a kind of active ultrasound imaging, but the imaging frame rate is low due to multiple line scans.

The active ultrasound imaging method based on plane waves can obtain the entire ultrasound image in a single shot, and the imaging frame rate is effectively improved, but because the plane wave itself is not focused and the emission energy is low, resulting in low imaging contrast, it is not conducive to focused ultrasound. High-sensitivity detection of residual phase-change microbubbles after irradiated phase-change nanodroplets stop

[0005] In addition, passive ultrasound imaging can only monitor the cavitation activity during focused ultrasound irradiation of phase-change nano-droplets, but cannot obtain the spatial distribution of phase-change microbubbles, while active ultrasound imaging can only achieve focusing Monitoring of Phase-Change Microbubbles after Phase-Change Nanodroplet Stopped by Ultrasonic Irradiation

Therefore, a single passive or active ultrasound imaging cannot realize the whole-process monitoring of phase-change nanodroplets irradiated by focused ultrasound.

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