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Application of aspartic acid in preparation of medicine for preventing and treating nonalcoholic fatty liver disease

A technology of aspartic acid and non-alcoholic, which is applied in the field of application of aspartic acid in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver, and can solve the problem of insulin receptor sensitizers, blood lipid-lowering drugs, liver cell Protective agents, angiotensin receptor antagonists, anti-cytokine inhibitors, intestinal microbiome regulators, limited efficacy, lack of specific intervention methods, etc.

Pending Publication Date: 2020-05-01
THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that have been developed or are being developed for NAFLD include drugs that reduce lipid peroxidation, insulin receptor sensitizers, blood lipid-lowering drugs, liver cell protection agents, angiotensin receptor antagonists, anti-cytokine inhibitors, intestinal Microbial regulators, etc., however, have limited efficacy in improving steatosis damage, fibrosis, etc.
The treatment of NAFLD still lacks specific intervention means, therefore, there is an urgent need to explore new mechanisms of the disease and develop new drugs

Method used

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  • Application of aspartic acid in preparation of medicine for preventing and treating nonalcoholic fatty liver disease
  • Application of aspartic acid in preparation of medicine for preventing and treating nonalcoholic fatty liver disease
  • Application of aspartic acid in preparation of medicine for preventing and treating nonalcoholic fatty liver disease

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Embodiment 1

[0025] NAFLD mouse model construction: NAFLD mouse model establishment and identification: 8-12 week-old male C57BL / 6 mice high-fat diet (HFD: containing 60% fat, purchased from Research Diets Company, item number D12492) or regular diet (SCD ) were fed for 12 weeks, and the levels of serum ALT, AST, and TG were detected by an automatic biochemical detector, and the pathological changes such as fatty degeneration of liver tissue were examined under the microscope after the above-mentioned oil red-hematoxylin staining, HE staining, and Masson staining. The results are shown in figure 1 . The test results showed that the NAFLD mouse model was successfully constructed after comparing with the conventional feeding mice.

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Abstract

The invention relates to an application of aspartic acid in preparation of a medicine for preventing and treating a nonalcoholic fatty liver disease (NAFLD). The invention explores for the first timean important biological effect of the aspartic acid in the occurrence and development of the NAFLD and the molecular mechanism, reveals the effect of aspartic acid metabolic abnormality in the development process of the NAFLD, and provides an important theoretical basis for aspartic acid intervention therapy; and through in-vivo in-vitro experiments, the invention clarifies for the first time themedicinal properties of the aspartic acid, establishes a system to evaluate the biological effectiveness and safety, and lays the foundation for subsequent standardized preclinical research of the medicine.

Description

[0001] (1) Technical field [0002] The invention relates to the application of aspartic acid in the preparation of medicines for preventing and treating non-alcoholic fatty liver. [0003] (2) Background technology [0004] Nonalcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by diffuse hepatic macrovesicular steatosis, which is not caused by alcohol and other definite liver injury factors. Studies in recent years have shown that the prevalence of NAFLD in adults in my country has reached about 20%, and it is increasing year by year; in developed countries such as the United States, the prevalence of NAFLD in adults is as high as 30%. NAFLD is not only the main cause of end-stage liver disease, but also promotes the occurrence and development of obesity, coronary heart disease, diabetes and other metabolic diseases [5] . Although NAFLD has become one of the major liver diseases, there are still many difficulties in its pathogenesis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P1/16
CPCA61K31/198A61P1/16
Inventor 虞朝辉张洁洪东升
Owner THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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