Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Coumarin dimer compound, pharmaceutical composition, and preparation method and application of the coumarin dimer compound

A technology of coumarins and compounds, which is applied in the field of natural medicinal chemistry, can solve the problem of lack of therapeutic drugs, and achieve the effects of improving expression and nerve cell damage.

Active Publication Date: 2020-04-28
CHINA RESOURCES SANJIU MEDICAL & PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new chemical entity called Coumaline Dimers improves how neurons are protected from amyloids that cause spongiform encephalopathies or other brain disorders like Parkinson's Disease. It also enhances neural growth factor production which helps with motor functioning at work better than previous drugs without causing side effectes on their own body.

Problems solved by technology

This patents discusses different aspects related to Amyopectina syndrome: genetic factors play crucial roles during childhood learning; environmental conditions affect brain function and mental performance. There may be other risk factors associated with this condition like smoking cigarettage use, alcohol consumption, excess weight gain due to lack of exercise, obstructed eatings, sleep disorders caused by stressors, abnormal behaviors, and social interactions involving older individuals. Current treatments focus primarily on symptom reduction but they can cause side effects.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Coumarin dimer compound, pharmaceutical composition, and preparation method and application of the coumarin dimer compound
  • Coumarin dimer compound, pharmaceutical composition, and preparation method and application of the coumarin dimer compound
  • Coumarin dimer compound, pharmaceutical composition, and preparation method and application of the coumarin dimer compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0092] The characterization of embodiment 2 formula I compound

[0093]

[0094] Ultraviolet spectrum (UV) shows strong absorption at 297nm and 326nm, indicating that the compound is a coumarin compound. High resolution mass spectrometry gave the molecular formula C 28 h 26 o 7 , [M+Na] + :497.1566(calcd 497.1576), see Figure 11 .

[0095] Compound (I) in 1 H-NMR spectrum (see Figure 12 ) low-field region showing characteristic hydrogen signals on a pair of coumarin backbones [δ H 6.20(1H, d, J=9.4Hz, H-3), 7.83(1H, d, J=9.4Hz, H-4)], and a set of hydrogen signals of the ABX system [δ H 7.54(1H,d,J=8.6Hz,H-5),7.09(1H,dd,J=8.6,2.3Hz,H-6),7.32(1H,d,J=2.3Hz,H-8)] , and a pair of coupled oxygen-proton signals [δ H 6.24 (1H, d, J=2.3Hz, H-9), 4.69 (1H,d, J=2.9Hz, H-10)]. At the same time, in 13 The C-NMR spectrum shows a total of 28 carbon signals, which are respectively assigned to two coumarin units, as shown in Table 1.

[0096] Compound (I) in 1 H- 1 In the...

preparation experiment example 1

[0100] Preparation experiment example 1 (preparation of injection)

[0101] Take 1000 mg of the compound represented by formula I obtained in Example 1 above, add 1000 ml of water for injection, adjust the pH value to 7 with sodium carbonate, stir to dissolve, sterilize and filter, pot, and circulate steam at 100 ° C for 15 minutes Sterilize, and make each injection containing 2mg / 2ml of the compound of formula I for injection.

preparation experiment example 2

[0102] Preparation experiment example 2 (preparation of capsules)

[0103]

[0104] Weigh the compound shown in formula I obtained in Example 1 according to the weight of the above formula, microcrystalline cellulose, sodium carboxymethyl starch, sodium lauryl sulfate, mix, adopt the roller compaction method to carry out dry granulation, and then mix with hard Magnesium fatty acid is mixed, filled into 3# hollow capsules, and made into capsules containing formula I compound 100mg / grain for oral use.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of natural pharmaceutical chemistry, and particularly provides a coumarin dimer compound, a pharmaceutical composition and a preparation method and application of the coumarin dimer compound. The coumarin dimer compound has a structure shown as a formula I shown in the specification. The coumarin dimer compound can remarkably improve nerve cell damage of an A[beta]1-42 induced senile dementia model; moreover, can improve neurotrophic factor expression, has anti-inflammatory and antioxidant effects, and can be used for preventing and treating nervous system degenerative diseases such as vascular dementia, vascular cognitive impairment, senile dementia (also called Alzheimer's disease), cholinergic neurodegenerative change, learning and memory ability decline and the like.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com