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Preparation method of high-strength polyvinyl alcohol hydrogel film

A polyvinyl alcohol and hydrogel film technology, which is applied in the preparation of polyvinyl alcohol hydrogel films and the preparation of high-strength polyvinyl alcohol hydrogel films, can solve problems such as insufficient stability and mechanical properties, and achieve Excellent biocompatibility, easy control of process parameters, and simple preparation method

Inactive Publication Date: 2020-04-28
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Natural polymers have well-defined biomedical applications and properties, such as non-toxic and biodegradable, but lack stability and mechanical properties

Method used

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  • Preparation method of high-strength polyvinyl alcohol hydrogel film
  • Preparation method of high-strength polyvinyl alcohol hydrogel film
  • Preparation method of high-strength polyvinyl alcohol hydrogel film

Examples

Experimental program
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preparation example Construction

[0029] (1) The preparation of a high-strength polyvinyl alcohol hydrogel film includes the carboxylation of polyvinyl alcohol, the preparation of PVA-COOH / gelatin solution, and the preparation of PVA-COOH / gelatin / chitosan hydrogel film.

[0030] (2) The raw materials for polyvinyl alcohol carboxylation are polyvinyl alcohol, 4-dimethylaminopyridine (DMAP), and succinic anhydride; the molar ratio of raw materials is, polyvinyl alcohol: DMAP: succinic anhydride = 10: 1: 10; In addition, the mass ratio of polyvinyl alcohol to water is 1:100.

[0031] (3) The raw material of the preparation of PVA-COOH / gelatin solution is carboxylated polyvinyl alcohol, gelatin, chitosan; Raw material mass ratio is, carboxylated polyvinyl alcohol: water=1: 25, carboxylated polyvinyl alcohol: gelatin : Chitosan = 1: 0.3-0.7: 0.3-0.7; In addition, ensure carboxylated polyvinyl alcohol: (gelatin + chitosan) = 1:1.

[0032] (4) The raw materials for the preparation of PVA-COOH / gelatin / chitosan hydrog...

example 1

[0038] A. Graft modification of polyvinyl alcohol

[0039] Add 5g of PVA powder and 500mL of deionized water into a 500ml three-neck flask, and heat to 90C under constant stirring. After the polyvinyl alcohol was dissolved, the temperature of the solution was cooled to 75°C, 1.385g of DMAP was added and stirred for 1h. At 75°C, 11.36g of succinic anhydride was added to the polyvinyl alcohol blend solution, and stirred at a constant speed of 400rpm / min for 24h. After the reaction was completed, the reaction solution was cooled to room temperature, and added dropwise to the frozen acetone solution with stirring, resulting in a white precipitate. The white precipitate (PVA-COOH) was collected, washed three times with acetone to remove unreacted raw materials, dried in a vacuum oven at room temperature overnight, and stored for future use.

[0040] B, the preparation of PVA-COOH / gelatin solution

[0041] Put 2.00g of PVA-COOH powder into a three-neck flask, add 50mL of deionized ...

example 2

[0045] A. Graft modification of polyvinyl alcohol

[0046] Add 5g of PVA powder and 500mL of deionized water into a 500ml three-neck flask, and heat to 90C under constant stirring. After the polyvinyl alcohol was dissolved, the temperature of the solution was cooled to 75°C, 1.385g of DMAP was added and stirred for 1h. At 75°C, 11.36g of succinic anhydride was added to the polyvinyl alcohol blend solution, and stirred at a constant speed of 400rpm / min for 24h. After the reaction was completed, the reaction solution was cooled to room temperature, and added dropwise to the frozen acetone solution with stirring, resulting in a white precipitate. The white precipitate (PVA-COOH) was collected, washed three times with acetone to remove unreacted raw materials, dried in a vacuum oven at room temperature overnight, and stored for future use.

[0047] B, the preparation of PVA-COOH / gelatin solution

[0048] Put 2.00g of PVA-COOH powder into a three-neck flask, add 50mL of deionize...

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Abstract

The invention provides a preparation method of a high-strength polyvinyl alcohol hydrogel film. The method comprises the following steps: taking polyvinyl alcohol as a raw material, firstly carrying out polyvinyl alcohol carboxylation, and adding gelatin and chitosan to achieve the purpose of synergistic interaction, constructing a polyvinyl alcohol physicochemical cross-linking system, and preparing the high-strength multi-network cross-linked hydrogel film. Due to the addition of the gelatin and the chitosan, the polyvinyl alcohol hydrogel film has higher strength and elongation, and the hydrogel film is endowed with unique antibacterial property and biocompatibility. The obtained polyvinyl alcohol hydrogel film has high tensile strength, has excellent moisturizing performance and antibacterial performance in a physiological environment, and can be used in the aspects of medical dressings and the like.

Description

technical field [0001] The invention relates to a preparation method of a polyvinyl alcohol hydrogel film, in particular to a preparation method of a high-strength polyvinyl alcohol hydrogel film, which belongs to the field of biological materials, especially the field of polymer wound dressings. Background technique [0002] Polyvinyl alcohol (PVA) hydrogel is chemically inactive, non-toxic, has good biocompatibility, excellent mechanical properties, high water absorption, and is easy to process and shape. It is widely used in agriculture, forestry, medicine, daily chemical industry, environmental protection And desert control and other fields. [0003] Tens of thousands of patients suffer epidermis or skin damage caused by various accidents every year, due to the limitation of skin self-repair, and the formation of scars. Wound dressings play a vital role in the wound healing process, protecting the wound site from further exogenous microorganisms and pain, and promoting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/46A61L15/24A61L15/32A61L15/28C08J3/075C08J5/18C08L29/04C08L89/00C08L5/08C08F8/14C08F116/06
CPCA61L15/24A61L15/28A61L15/32A61L15/42A61L15/46C08F8/14C08J3/075C08J5/18C08J2329/04C08J2405/08C08J2489/00C08L29/04C08L89/00C08L5/08C08F116/06
Inventor 孙志洁张志巩建乐
Owner HARBIN ENG UNIV
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