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Flower-like zinc phosphate nanoparticle antibacterial material and preparation method and application thereof

Active Publication Date: 2020-04-21
河北凯恩利生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent CN 108823964 A discloses a preparation method of zinc oxide-silver composite antibacterial cotton fabric, but the preparation time is long, silver powder needs to be added, the cost is high, and the requirements are relatively high
Chinese patent CN 109440524 A discloses a preparation method of antibacterial paper loaded with nano-zinc oxide, but the reaction temperature is high and the preparation time is long, which has become a concern that cannot be ignored
Chinese patent CN 104416986 A discloses nano zinc oxide antibacterial composite material, but its preparation method is relatively complicated
Chinese patent CN 105494434 A discloses the preparation method of zinc oxide antibacterial composite material, the preparation temperature is as high as 500°C, the preparation time is longer and the operating conditions are more demanding
Chinese patent CN 107252395 A discloses a composition containing zinc phosphate, and its preparation components are relatively complicated
The above technologies all have various problems such as harsh preparation conditions and high cost.

Method used

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  • Flower-like zinc phosphate nanoparticle antibacterial material and preparation method and application thereof
  • Flower-like zinc phosphate nanoparticle antibacterial material and preparation method and application thereof
  • Flower-like zinc phosphate nanoparticle antibacterial material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1 Preparation of antibacterial material of flower-like zinc phosphate nanoparticles controlled by isoorotic acid

[0061] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:

[0062] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.01mol / LNa 2 HPO 4 ·12H 2 In O solution, make a composite solution;

[0063] (2) Adjust the pH value of the above solution to 8.0 with 2mol / L NaOH, until it is completely dissolved, and set aside;

[0064] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.3mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.

[0065] (4) Place the precipitate obtained in step (3) in a freeze-vacuum dryer at -45° C. and a pressure of 5 Pa. The freeze-drying time is 8 hours. The flower-shaped zin...

Embodiment 2

[0067] Example 2 Preparation of flower-like zinc phosphate nanoparticle antibacterial material regulated by isorotic acid

[0068] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:

[0069] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.01mol / LNaH 2 PO 4 ·2H 2 In O solution, make a composite solution;

[0070] (2) Adjust the pH value of the above solution to 8.0 with 2mol / L NaOH, until it is completely dissolved, and set aside;

[0071] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.3mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.

[0072] (4) The precipitate obtained in step (3) is placed in a freeze-vacuum dryer at -45°C and a pressure of 1-10 Pa, and the freeze-drying time is 6-12 hours. The flower-like ...

Embodiment 3

[0074] Example 3 Preparation of antibacterial material of flower-like zinc phosphate nanoparticles controlled by isorotic acid

[0075] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:

[0076] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.1mol / LNa 2 HPO 4 ·12H 2 In O solution, make a composite solution;

[0077] (2) Adjust the pH value of the above solution to 8.5 with 2mol / L NaOH, until it is completely dissolved, and set aside;

[0078] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.4mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.

[0079] (4) The precipitate obtained in step (3) is placed in a freeze-vacuum dryer at -45°C and a pressure of 1-10 Pa, and the freeze-drying time is 6-12 hours. The flower-...

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Abstract

The invention discloses a flower-like zinc phosphate nanoparticle antibacterial material and a preparation method and application thereof, belonging to the technical field of anticorrosive materials.According to the preparation method, 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) is used for regulating and controlling a reaction of sodium phosphate with zinc salt, a formed nano-particle material is separated out of a solution in a precipitate form, and the flower-like zinc phosphate nano-particle antibacterial material is prepared through centrifugation, supernatant removal, washing and freeze drying. According to the antibacterial material prepared by the invention, the specific surface area of zinc phosphate is increased by a flower-shaped structure, so the antibacterial material can contact more microbial thalli, achieves a more obvious antibacterial effect and has good inhibition effects on Bacillus subtilis, Staphylococcus aureus, Salmonella enteritidis and a plurality of antibiotic-resistant strains; meanwhile, the material has the characteristics of low toxicity, small side effect, good biological safety and the like; and the preparation method has the advantages of simple preparation process, high operability and good market application prospects.

Description

Technical field [0001] The invention belongs to the technical field of antiseptic materials, and specifically relates to a flower-shaped zinc phosphate nano-particle antibacterial material and a preparation method and application thereof. Background technique [0002] In the past few decades, environmental pollution caused by pathogenic bacteria has threatened human health, posing unprecedented challenges to the research of sterilization and bacteriostasis. Therefore, it is very urgent to develop efficient and safe sterilization and antibacterial materials. Studies have found that some nanomaterials have antibacterial or bactericidal properties, which are different from other antibacterial agents. Nanomaterials exhibit better antibacterial effects due to their smaller size and larger surface area. [0003] Nano-zinc particle materials (common nano-zinc oxide) have been applied in many fields such as agriculture, chemistry, medicine and food. As a new type of inorganic antibacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/37A61K33/42A61P31/04
CPCA61K33/42A61P31/04C01B25/37C01P2004/03C01P2004/30Y02A50/30
Inventor 崔建东刘洋冯玉晓贾士儒
Owner 河北凯恩利生物技术有限公司
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