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Preparation method of hemostatic agent with rapid diffusion mixing function

A diffusion mixing and hemostatic agent technology, applied in surgical adhesives, pharmaceutical formulations, applications, etc., can solve the problems of not having rapid diffusion and rapid coagulation, easy to be washed away by blood, and unsatisfactory hemostasis effect, etc., to achieve good bioavailability Effects of degradability, coagulation phase and kinetic phase stabilization, good biocompatibility

Active Publication Date: 2020-04-21
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current powder hemostatic materials including the above-mentioned patents are easy to be washed away by the blood when the wound is bleeding rapidly, and do not have the function of rapid diffusion to achieve rapid blood coagulation, especially in open wounds with a large amount of bleeding. Under the physical impact of blood, these powder hemostatic materials are often washed away before coagulating the blood after being sprinkled on the wound, so the hemostatic effect is not ideal

Method used

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  • Preparation method of hemostatic agent with rapid diffusion mixing function
  • Preparation method of hemostatic agent with rapid diffusion mixing function
  • Preparation method of hemostatic agent with rapid diffusion mixing function

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A rapid diffusion mixed function hemostatic agent, its preparation method comprises the following steps:

[0044] S1: Add 40g of cornstarch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 40°C and stir at a speed of 250r / m for 10h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.6 g of sodium carbonate and 1.2 g of sodium trimetaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to cornstarch is 2: 100.

[0045] S2: Stir 10 g of the esterified microporous starch obt...

Embodiment 2

[0049] A rapid diffusion mixed function hemostatic agent, its preparation method comprises the following steps:

[0050] S1: Add 40g of tapioca starch to 200ml of sodium acetate buffer solution containing α-amylase and glucoamylase at a pH of 4.6 to react, heat at 35°C and stir at a speed of 250r / m for 12h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.2 g of sodium carbonate and 0.8 g of sodium hexametaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase and glucoamylase is 1:4, and the ratio of amylase and tapioca starch is 2: 100.

[0051] S2: Stir and mix 10 g of the esterified microporo...

Embodiment 3

[0055] A rapid diffusion mixed function hemostatic agent, its preparation method comprises the following steps:

[0056] S1: Add 40g of wheat starch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 55°C and stir at a speed of 250r / m for 6h, filter after the reaction is completed, clean the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 2 g of sodium carbonate and 4 g of sodium tripolyphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the pH value of the solution After the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to wheat starch is 2:100.

[0057] S2: Stir and mix 10g of the esterified microporous starch ob...

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Abstract

The invention aims at overcoming the defect that the existing hemostatic research and product cannot go deep into the wound to stop bleeding. The invention provides a preparation method of a hemostatic agent with rapid diffusion mixing function. The preparation method comprises following steps: depositing and growing sodium bicarbonate on esterified microporous starch to obtain esterified microporous starch / sodium bicarbonate particles; and immobilizing and assembling thrombin on the surfaces of the esterified microporous starch / sodium bicarbonate particles to obtain thrombin-assembled esterified microporous starch / sodium bicarbonate particles, and mixing the thrombin-assembled esterified microporous starch / sodium bicarbonate particles with a protonated acidic salt powder to obtain the hemostatic agent with rapid diffusion mixing function. By means of the characteristic that esterified microporous starch / sodium bicarbonate particles can achieve rapid diffusion mixing hemostasis in a specific microenvironment, the sealing effect is achieved on the whole blood cavity and the wound surface of a wound, and three-dimensional hemostasis of the wound is achieved.

Description

technical field [0001] The invention is applied in the technical field of hemostatic materials, and in particular relates to a preparation method of a rapid diffusion mixed function hemostatic agent. Background technique [0002] The new powder hemostatic material is a type of product that realizes hemostasis by concentrating blood coagulation factors based on the water absorption mechanism of molecular sieves. Thanks to its excellent liquid-like fluidity, it is suitable for the control of various irregular wound bleeding. Among them, the most representative one is the starch-based powder hemostatic material. Compared with traditional inorganic powder hemostatic materials (zeolite, kaolin and montmorillonite, etc.), starch-based powder has a natural microsphere structure, generally 10-80 μm in diameter, has a larger specific surface area, and can quickly absorb blood Water can effectively concentrate the coagulation components in the blood, and then form a gel-like mixture ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/08A61L2300/254A61L2300/418A61L2400/04C08L3/06
Inventor 蓝广芊李庆胡恩岭陆飞谢瑞琪余堃
Owner SOUTHWEST UNIV
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