Preparation method of zinc oxide-metal organic framework composite antibacterial material

A technology of metal-organic frameworks and composite materials, which is applied in the field of preparation of zinc oxide-metal-organic framework composite antibacterial materials, can solve problems such as easy agglomeration and affecting antibacterial performance, and achieve orderly and uniform pores, high-efficiency antibacterial effect, and high ratio The effect of surface area

Inactive Publication Date: 2020-04-21
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the high specific surface energy and strong surface polarity of...

Method used

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  • Preparation method of zinc oxide-metal organic framework composite antibacterial material

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Embodiment 1

[0020] A zinc oxide-metal organic framework composite antibacterial material, using lanthanide MOFs with good biological properties and easy preparation as the framework material; MOFs-Ln is made of thiol diacetic acid (TDA) and lanthanide nitrate, and is stripped in two steps , Adjust the particle size and porosity of MOFs-Ln to obtain different sizes of MOFs structure; then, in-situ growth is used to grow ZnO NPs on the surface and pores of MOFs-Ln using zinc nitrate, sodium hydroxide and sodium chloride , Get the ZnONPs@MOFs-Ln material with good antibacterial properties, and prepare it according to the following steps:

[0021] (1) Preparation of MOFs-Ln:

[0022] 1) Synthesis: Take 0.4 mmol TDA and 0.2 mmol lanthanide nitrate La(NO 3 ) 3 Dissolve in 40 mL of 60 mmol sodium hydroxide (Na OH) solution, mix well, transfer to a 50 mL reactor, react at 150 ℃ for 24 hours, after the reaction, filter off the supernatant, and use CH for precipitation 3 CH 2 -OH cleaned three times and...

Embodiment 2

[0028] A zinc oxide-metal organic framework composite antibacterial material, similar to Example 1, is prepared according to the following steps:

[0029] (1) Preparation of MOFs-Ln:

[0030] 1) Synthesis: Take 0.8mmol TDA and 0.4mmol lanthanide nitrate Nd(NO 3 ) 3 Dissolve in 40 mL 70 mmol Na OH solution, mix well, transfer to a 50 mL reactor, react at 140 ℃ for 24 hours, after the reaction, filter off the supernatant, and use CH for precipitation 3 CH 2 -OH cleaned three times and dried at 60 ℃ to obtain MOFs-Ln for use;

[0031] 2) Stripping: Dissolve 10 mg MOFs-Ln in 3 mL CH 3 CH 2 In -OH, ultrasonic for 30 min, centrifuge to collect the part of MOFs-Ln that fell off, and wash with n-hexane 3 times, dissolve the precipitate in 10 mL n-hexane solution containing 0.2 mM n-butyllithium, and place it at room temperature and N 2 Under protected conditions, fully stir overnight, centrifuge the above reaction solution, remove the supernatant, and use 10 mL CH for precipitation 3 CH 2 -OH...

Embodiment 3

[0036] A zinc oxide-metal organic framework composite antibacterial material, similar to Example 1, is prepared according to the following steps:

[0037] (1) Preparation of MOFs-Ln:

[0038] 1) Synthesis: Take 1 mmol TDA and 0.5 mmol lanthanide nitrate Eu(NO 3 ) 3 Dissolve in 40 mL 80 mM Na OH solution, mix well, transfer to a 50 mL reactor, react at 160 ℃ for 20 hours, after the reaction, filter off the supernatant and use CH for precipitation 3 CH 2 -OH cleaned three times and dried at 60 ℃ to obtain MOFs-Ln for use;

[0039] 2) Stripping: Dissolve 10 mg MOFs-Ln in 3 mL CH 3 CH 2 In -OH, ultrasonic for 30 min, centrifuge to collect the part of MOFs-Ln that fell off, and wash with n-hexane 3 times, dissolve the precipitate in 10 mL n-hexane solution containing 0.2 mM n-butyllithium, and place it at room temperature and nitrogen (N 2 ) Under protected conditions, stir well overnight, centrifuge the above reaction solution, remove the supernatant, and use 10 mL CH for precipitation 3 ...

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Abstract

The invention relates to a preparation method of a zinc oxide-metal organic framework composite antibacterial material. Lanthanide-series MOFs which are good in biological property and easy to prepareare adopted as a framework material; the MOFs-Ln is prepared from thiodiacetic acid (TDA) and lanthanide nitrate. Through two-step stripping, the particle sizes and porosity of the MOFs-Ln can be adjusted, so MOFs structures of different sizes are obtained; and then, zinc nitrate, sodium hydroxide and sodium chloride are used for growing ZnO NPs on the surface and in pores of the MOFs-Ln in an in-situ growth mode, so the ZnO NPs@MOFs-Ln material with good antibacterial performance can be obtained. The morphology and particle size of MOFs-Ln can be regulated and controlled by changing the content and reaction time of TDA and lanthanide nitrate and changing a stripping mode, so the subsequent growth size of ZnO NPs is influenced, and the generation of nanoscale ZnO particles with high antibacterial activity is limited; and the material has efficient antibacterial effects.

Description

Technical field [0001] The invention relates to the preparation and application of a novel antibacterial material. Specifically, it relates to a method for preparing a zinc oxide-metal organic frame composite antibacterial material. The invention belongs to the field of nano antibacterial materials. Background technique [0002] Pathogenic microorganisms are widely distributed in nature, and their excessive growth, reproduction and mutation will seriously affect human health and lifespan. In particular, there is an increasing demand for antibacterial materials in areas closely related to human life such as textiles, food packaging, and medical materials. Therefore, there is an urgent need to develop new antibacterial materials with broad antibacterial properties and high sterilization properties. [0003] Currently commonly used antibacterial materials mainly include: silver-based antibacterial materials (Chinese patent: a nano-silver antibacterial material and its preparation me...

Claims

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Application Information

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IPC IPC(8): A01N25/10A01N59/16C09K11/06A01P1/00
CPCA01N25/10A01N59/16C09K11/06C09K2211/182
Inventor 崔大祥徐艳陈玮嘉张兆坤朱君金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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