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Preparation method of a drug-carrying system for nerve repair with electrical stimulation and angiogenesis-promoting effects

A technology that promotes angiogenesis and nerve repair. It is used in medical science, electrospinning, tissue regeneration, etc. It can solve the problems of unsatisfactory repair effect of peripheral nerve damage and low nerve tissue regeneration ability, and achieve excellent biocompatibility, The effect of not hindering nerve regeneration and ensuring flexibility

Active Publication Date: 2021-06-08
深圳南泥湾科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the characteristics of highly differentiated nerve tissue and low regeneration ability, the repair effect of peripheral nerve injury is still unsatisfactory.

Method used

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  • Preparation method of a drug-carrying system for nerve repair with electrical stimulation and angiogenesis-promoting effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 1.0g of natural graphite powder and 0.5g of sodium nitrate into a three-necked flask, place the three-necked flask in an ice bath and slowly add 23mL of concentrated sulfuric acid, continue stirring for 15min and then slowly add 4g of potassium permanganate to keep the system temperature constant Stirring was continued over 20 °C for 2 h. After removing the ice bath, the mixture in the three-necked flask was heated to 35°C and kept stirring for 1.5h, then slowly added 46mL of deionized water, and kept the system temperature at 98°C and vigorously stirred for 30min. The three-neck flask was placed in air to cool naturally, and 140 mL of deionized water and 10 mL of hydrogen peroxide were added thereto to terminate the reaction, at which point the suspension in the flask turned bright yellow. After centrifugation, the filter cake was fully washed with 5% HCl aqueous solution and deionized water in sequence until neutral or close to neutral, and then freeze-dried to ob...

Embodiment 2

[0028] The present embodiment is basically the same as Example 1, except that the concentration of GO suspension is changed from 1% to 2%, the concentration of gelatin aqueous solution is changed from 20% to 15%, and the concentration of chitosan solution is changed from 3% to 2%. is 4%, and the mixing ratio of the three remains unchanged.

Embodiment 3

[0030] The present embodiment is basically the same as Example 1, except that the concentration of GO suspension is changed from 1% to 3%, the concentration of gelatin aqueous solution is changed from 20% to 15%, and the concentration of chitosan solution is changed from 3% to 3%. is 4%, and the mixing ratio of the three remains unchanged.

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Abstract

The invention relates to a drug-carrying system for nerve repair with bioelectric stimulation and angiogenesis-promoting effects and a preparation method thereof. The gelatin, chitosan, polylactic acid and other natural polymer components in the nerve repair drug delivery system ensure good biocompatibility and non-toxicity, and the polylactic acid can also meet the good mechanical performance requirements of the catheter and avoid the process of nerve growth The medium catheter collapses, and the excellent flexibility prevents nerve regeneration from being hindered. The introduction of the conductive copolymer GO makes the catheter have weak conductivity, which meets the needs of human physiological current and helps to accelerate nerve repair; the introduction of VEGF growth factor can maximize the bionic extracellular matrix microenvironment in the human body, and promote microvascular regeneration from the direction of accelerating microvascular regeneration. Nerve repair, ultimately improving the quality of nerve injury repair.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a drug-carrying system for nerve repair with bioelectric stimulation and angiogenesis-promoting effects and a preparation method thereof. Background technique [0002] Peripheral nerve injury, especially long-segment nerve defect, has been an important topic in neuroscience research for a long time, and it is also one of the problems to be solved urgently in the medical field. Studies have shown that although peripheral nerves have a certain ability to regenerate, the regenerative ability is low and easily blocked by the surrounding scars, causing the regenerated axons to disperse and eventually form neuromas. Currently, autologous nerve transplantation is considered the gold standard for the treatment of peripheral nerve injuries. In recent years, with the great development of tissue engineering, it has brought new hope for peripheral nerve regeneration. The const...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/20A61L27/08A61L27/18A61L27/38A61L27/50A61L27/54A61L27/56A61F2/00D01D5/00
CPCA61F2/00A61F2002/0086A61L27/08A61L27/18A61L27/20A61L27/222A61L27/227A61L27/383A61L27/3878A61L27/50A61L27/54A61L27/56A61L2430/32D01D5/003D01D5/0069D01D5/0092
Inventor 徐海星李锐许沛虎黄志军宁偲偲张婉婷闫秀美马毓聪李意璇李信
Owner 深圳南泥湾科技有限公司
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