Thymus-dependent lymphocyte antigen epitope peptides of primary liver cancer related antigens and application thereof

Abstract

The invention belongs to the field of medical immunology and oncology and discloses thymus-dependent lymphocyte antigen epitope peptides of primary liver cancer related antigens and application thereof. The antigen epitope peptides are antigen peptides separately restricted by HLA-A0201, HLA-A1101, hLA-A2402, HLA-A3101, HLA-A0206, HLA-A0207, HLA-A3303, HLA-A3001, HLA-A0203, HLA-A1102, HLA-A0301, HLA-A0101 and HLA-A2601 molecules, and the varieties of the antigen epitope peptides sum to 110. The antigen epitope peptides can specifically bind to cytotoxic thymus-dependent lymphocytes so as to stimulate the activation, proliferation and differentiation of the thymus-dependent lymphocytes, so anti-tumor immune effect is exerted; the antigen peptides can be used for preparing therapeutic and preventive vaccines for liver cancer, can also be used for preparing detection reagents for detecting liver cancer-related antigen-specific cytotoxic thymus-dependent lymphocytes, and have potential application value in prevention, treatment and diagnosis of liver cancer.

Description

technical field [0001] The invention belongs to the fields of medical immunology and oncology, and particularly relates to three primary liver cancer-related antigen thymus-dependent lymphocyte antigen epitope peptides and applications thereof. Background technique [0002] Primary liver cancer is the fourth common malignant tumor and the third leading cause of tumor death in my country, which seriously threatens the life and health of our people. The pathological types of primary liver cancer are mainly hepatocellular carcinoma (HCC), accounting for 85% to 90%; there are also a few intrahepatic cholangiocarcinoma (ICC) and HCC-ICC mixed types, etc. The pathogenesis, biological behavior, molecular characteristics, clinical manifestations, histopathological morphology, treatment methods and prognosis are quite different among the three. [0003] In my country, high-risk groups for HCC mainly include hepatitis B virus (HBV) and / or hepatitis C virus (HCV) infection, long-term ...

AI Technical Summary

Problems solved by technology

[0007] However, there are still very few primary liver cancer-associated antigen T-cell epitopes that are presented by various HLA molecules and can stimulate the body to trigger T-cell responses, which limits the research on liver cancers carrying different HLA alleles. The detection of specific T cells in patients also limits the research on the role of liver cancer-specific T cells in the occurrence and development of liver cancer, and limits the personalized detection and analysis based on the individual differences of HLA genes and the differences of the liver cancer-related antigen peptides presented. Precision Immunotherapy

Images