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A silica gel low temperature modeling animal experiment device

A technology of animal experiments and silica gel, applied in veterinary surgery, medical science, veterinary instruments, etc., can solve the problems of fast heating temperature, inability to replicate uniform injury models, and slow cooling

Active Publication Date: 2022-04-26
涂发妹 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Journal of Lanzhou Medical College, Volume 27, No. 1, March 2001, Liu Yi, Xue Xiaodong, Jia Chiyu, et al. "Experimental research on the establishment of a mouse scald model with a constant temperature and constant voltage electric scald instrument". Its heating temperature is fast and cooling is slow, and the electric iron block is unstable and the pressure is uneven when the hand is held for a long time, and the plane of the electric iron block and the animal skin plane cannot reach the same plane pressure, and the uniform injury model cannot be reproduced. Low temperature injury modeling methods vary greatly
The patent document with the patent application number CN201710943082.7 discloses "a portable digital temperature-controlled scald instrument", which is used for high-temperature scald animal experimental equipment, and is suitable for the production of common skin scald models of mice, rats, rabbits, and miniature pigs. ; The three documents retrieved above are all suitable for making animal burn models, but they are far from low-temperature burn model making methods, and low-temperature burns are slowly and gradually damaged from the superficial layer of the skin to the deep layer of the dermis, and the degree of damage is related to the low-temperature exposure time relevant

Method used

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  • A silica gel low temperature modeling animal experiment device
  • A silica gel low temperature modeling animal experiment device
  • A silica gel low temperature modeling animal experiment device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Choose healthy mixed-breed domestic dogs, weighing (14.38±3.13) kg, (16.12±2.5) kg each, male or female, intraperitoneal injection of 3% pentobarbital sodium 30 mg / kg for anesthesia, after the anesthesia is stable, the animals are treated with The 8% sodium sulfide solution was used to gently remove the hair with a circular diameter of 5 cm on the right upper abdomen of the model dog, and wipe off the excess drug solution on the skin with wet gauze as soon as possible after hair removal. Then put the animal dog prone on the animal experiment convex platform (1), hang the animal anesthesia maintenance medicine and injection medicine on the convex platform hook (2) for standby; put the dog's head into the two left ends of the convex platform simultaneously. The fixed rods (3) are fixed; start the power switch (14), press the table width adjustment button (15), the running screw is stabilized by the bearing (16), and the DC motor (19) drives the screw (18) to rotate, Nut (...

Embodiment 2

[0029] Choose healthy mixed-breed domestic dogs, weighing (14.38±3.13) kg, (16.12±2.5) kg each, male or female, intraperitoneal injection of 3% pentobarbital sodium 30 mg / kg for anesthesia, after the anesthesia is stable, the animals are treated with The 8% sodium sulfide solution was used to gently remove the hair with a circular diameter of 5 cm on the right upper abdomen of the model dog, and wipe off the excess drug solution on the skin with wet gauze as soon as possible after hair removal. Then put the animal dog prone on the animal experiment convex platform (1), hang the animal anesthesia maintenance medicine and injection medicine on the convex platform hook (2) for standby; put the dog's head into the two left ends of the convex platform simultaneously. The fixed rods (3) are fixed; start the power switch (14), press the table width adjustment button (15), the running screw is stabilized by the bearing (16), and the DC motor (19) drives the screw (18) to rotate, Nut (...

Embodiment 3

[0031]Select 1 white rabbit of 2550g, 2 each of 2800g; 2 each of 2620g, 5 in total, use the silica gel low-temperature modeling animal experiment device of the present invention to carry out the experiment on 5 white rabbits one by one under the same conditions of 45°C and 7 hours. Silica gel low temperature modeling experiment. One day before modeling, use 8% sodium sulfide solution to gently remove the hair of the modeling site. On the day of modeling, use 10% chloral hydrate (300ml / kg) to anesthetize the abdominal cavity, and then put the white rabbit prone on the animal experiment convex shape. Platform (1), hang animal drinking water or urgently needed medicines on the protruding platform suspension hook (2) for standby use, and the big white rabbit head is fixed at the animal head fixed bar (3); start power switch (14), Press the table width adjustment button (15), the running screw is stabilized by the bearing (16), the DC motor (19) drives the screw (18) to rotate, and...

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Abstract

The purpose of the present invention is to provide a stable, repeatable, and easy-to-operate silicone low-temperature modeling animal experiment device. The device uses a convex animal experiment platform made of stainless steel, and the table can be selected according to the size of the animal. Table top constant temperature function and fixed position of animal limbs. Animal low-temperature modeling tools use soft silicone low-temperature heating sheets combined with portable elastic bandages, and the silicone low-temperature heating sheets are attached to the animal epidermis to create clinical low-temperature injury models. The device is accurate and reliable for making low temperature models of animals. It can be automatically controlled by digital display after setting the temperature and time. It does not need to damage the skin of the animal and can be operated on any skin part of the animal. It is convenient to make low temperature models of different areas and depths.

Description

technical field [0001] This application relates to a low-temperature burn that has a low base temperature but the skin is in contact with a low-heat object higher than body temperature (37°C) for a long time, resulting in heat accumulation and scalding of the skin and subcutaneous tissue at the contact site, which is called low-temperature burn. A treatment model for low-temperature scalds with difficult-to-heal wounds, especially a silica gel low-temperature modeling animal experimental device. Background technique [0002] Low-temperature burns can also be called low-temperature burns, which are progressive damages from the superficial layer of the skin to the deep layer of the dermis and subcutaneous tissues. It is generally believed that continuous contact with a heat source at 70°C for 1 minute can cause full-thickness damage to the epidermis; continuous contact with a heat source at 40°C for 6 hours can cause irreversible damage to the basal cells of the skin. The tem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 涂发妹聂焕雄郭光华胡鹏聂玉花
Owner 涂发妹
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