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Silica gel hypothermia model-making animal experimental device

An animal experiment, silica gel technology, used in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of incapable of replicating uniform injury models, fast heating temperature, uneven pressure, etc.

Active Publication Date: 2020-03-31
涂发妹 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Journal of Lanzhou Medical College, Volume 27, No. 1, March 2001, Liu Yi, Xue Xiaodong, Jia Chiyu, et al. "Experimental research on the establishment of a mouse scald model with a constant temperature and constant voltage electric scald instrument". Its heating temperature is fast and cooling is slow, and the electric iron block is unstable and the pressure is uneven when the hand is held for a long time, and the plane of the electric iron block and the animal skin plane cannot reach the same plane pressure, and the uniform injury model cannot be reproduced. Low temperature injury modeling methods vary greatly
The patent document with the patent application number CN201710943082.7 discloses "a portable digital temperature-controlled scald instrument", which is used for high-temperature scald animal experimental equipment, and is suitable for the production of common skin scald models of mice, rats, rabbits, and miniature pigs. ; The three documents retrieved above are all suitable for making animal burn models, but they are far from low-temperature burn model making methods, and low-temperature burns are slowly and gradually damaged from the superficial layer of the skin to the deep layer of the dermis, and the degree of damage is related to the low-temperature exposure time relevant

Method used

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  • Silica gel hypothermia model-making animal experimental device
  • Silica gel hypothermia model-making animal experimental device
  • Silica gel hypothermia model-making animal experimental device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Choose healthy mixed-breed domestic dogs, weighing (14.38±3.13) kg, (16.12±2.5) kg each, male or female, intraperitoneal injection of 3% pentobarbital sodium 30 mg / kg for anesthesia, after the anesthesia is stable, the animals are treated with The 8% sodium sulfide solution was used to gently remove the hair with a circular diameter of 5 cm on the right upper abdomen of the model dog, and wipe off the excess drug solution on the skin with wet gauze as soon as possible after hair removal. Then put the animal dog prone on the animal experiment convex platform (1), hang the animal anesthesia maintenance medicine and injection medicine on the convex platform hook (2) for standby; put the dog's head into the two left ends of the convex platform simultaneously. The fixed rods (3) are fixed; start the power switch (14), press the table width adjustment button (15), the running screw is stabilized by the bearing (16), and the DC motor (19) drives the screw (18) to rotate, Nut (...

Embodiment 2

[0029] Choose healthy mixed-breed domestic dogs, weighing (14.38±3.13) kg, (16.12±2.5) kg each, male or female, intraperitoneal injection of 3% pentobarbital sodium 30 mg / kg for anesthesia, after the anesthesia is stable, the animals are treated with The 8% sodium sulfide solution was used to gently remove the hair with a circular diameter of 5 cm on the right upper abdomen of the model dog, and wipe off the excess drug solution on the skin with wet gauze as soon as possible after hair removal. Then put the animal dog prone on the animal experiment convex platform (1), hang the animal anesthesia maintenance medicine and injection medicine on the convex platform hook (2) for standby; put the dog's head into the two left ends of the convex platform simultaneously. The fixed rods (3) are fixed; start the power switch (14), press the table width adjustment button (15), the running screw is stabilized by the bearing (16), and the DC motor (19) drives the screw (18) to rotate, Nut (...

Embodiment 3

[0031]Select 1 white rabbit of 2550g, 2 each of 2800g; 2 each of 2620g, 5 in total, use the silica gel low-temperature modeling animal experiment device of the present invention to carry out the experiment on 5 white rabbits one by one under the same conditions of 45°C and 7 hours. Silica gel low temperature modeling experiment. One day before modeling, use 8% sodium sulfide solution to gently remove the hair of the modeling site. On the day of modeling, use 10% chloral hydrate (300ml / kg) to anesthetize the abdominal cavity, and then put the white rabbit prone on the animal experiment convex shape. Platform (1), hang animal drinking water or urgently needed medicines on the protruding platform suspension hook (2) for standby use, and the big white rabbit head is fixed at the animal head fixed bar (3); start power switch (14), Press the table width adjustment button (15), the running screw is stabilized by the bearing (16), the DC motor (19) drives the screw (18) to rotate, and...

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Abstract

The purpose of the invention is to provide a silica gel hypothermia model-making animal experimental device which is stable in preparation, high in repeatability and easy to operate. The silica gel hypothermia model-making animal experimental device selects an animal experiment convex table made of stainless steel; and a table top with suitable table top width can be selected according to size ofan animal. Moreover, the animal experiment convex table has a table top constant-temperature function, as well as animal limb fixtures. The silica gel hypothermia model-making animal experimental device adopts combination of soft silica gel hypothermia heating sheets with portable elastic bandages as hypothermia animal modeling tools, so that hypothermia injury models in accordance with clinical requirements can be made by just attaching the silica gel hypothermia heating sheets to the animal skin. The silica gel hypothermia model-making animal experimental device is capable of preparing accurate and reliable animal hypothermia models; and moreover, automatic digital display control can be realized by just setting temperature and time without damages on animal skin, and can be operated atany part of the animal skin, thereby facilitating preparation of hypothermia models of different sizes and different depths.

Description

technical field [0001] This application relates to a low-temperature burn that has a low base temperature but the skin is in contact with a low-heat object higher than body temperature (37°C) for a long time, resulting in heat accumulation and scalding of the skin and subcutaneous tissue at the contact site, which is called low-temperature burn. A treatment model for low-temperature scalds with difficult-to-heal wounds, especially a silica gel low-temperature modeling animal experimental device. Background technique [0002] Low-temperature burns can also be called low-temperature burns, which are progressive damages from the superficial layer of the skin to the deep layer of the dermis and subcutaneous tissues. It is generally believed that continuous contact with a heat source at 70°C for 1 minute can cause full-thickness damage to the epidermis; continuous contact with a heat source at 40°C for 6 hours can cause irreversible damage to the basal cells of the skin. The tem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 涂发妹聂焕雄郭光华胡鹏聂玉花
Owner 涂发妹
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