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Ipratropium bromide spray containing surfactant

A technology of ipratropium bromide and surfactant, applied in the field of ipratropium bromide spray containing surfactant, can solve problems such as the influence of surface tension spray particle size, spray time, spray speed, etc.

Inactive Publication Date: 2020-03-13
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] But all do not introduce the impact of surface tension on the spray particle size, spray time, spray velocity of this propellant-free spray medicine composition in these documents

Method used

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  • Ipratropium bromide spray containing surfactant
  • Ipratropium bromide spray containing surfactant
  • Ipratropium bromide spray containing surfactant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation method: uniformly mix ipratropium bromide or ipratropium bromide monohydrate with water whose pH value is adjusted with hydrochloric acid, and adjust the surface tension of the overall solution to the following table with an aqueous solution of an inhalable surfactant.

[0030] Pharmaceutical preparation of 100ml:

[0031]

[0032]

Embodiment 2

[0034] Preparation method: mix ipratropium bromide or ipratropium bromide monohydrate, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to the following table.

[0035] Pharmaceutical preparation of 100ml:

[0036]

[0037]

[0038]

Embodiment 3

[0040] Preparation method: mix ipratropium bromide or ipratropium bromide monohydrate, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to the following table.

[0041] Pharmaceutical preparation of 100ml:

[0042]

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Abstract

The invention relates to a drug ipratropium bromide spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant can makethe spray particle size, the spray time and the spray speed of the composition more suitable by adjusting the surface tension of the ipratropium bromide spray pharmaceutical composition without a propellant.

Description

Technical field: [0001] The present invention relates to the drug tiotropium bromide spray for the treatment of respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc., wherein the inhalable surfactant can be adjusted by adjusting the drug combination of tiotropium bromide aerosol without propellant The surface tension of the material makes the spray particle size, spray time and spray speed of the composition more suitable. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/24A61K47/10A61K31/46A61P11/06
CPCA61K9/0073A61K47/24A61K47/10A61K31/46A61P11/06
Inventor 张杰孙亮
Owner TIANJIN JINYAO GRP
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