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Oral caring composition and application thereof in inhibiting gum bleeding

A technology of oral care and composition, applied in the field of oral care, to achieve the effect of solving gum bleeding and inhibiting gum bleeding

Inactive Publication Date: 2020-03-10
HAWLEY & HAZEL BVI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral care composition of the present invention can achieve four coagulation indicators: prothrombin time (PT)≤14.5 seconds; thrombin time (TT)≤42.5 seconds; activated partial thromboplastin time (APTT)≤27.0 seconds; platelet aggregation Rate ≥ 53.5; can effectively solve the problem of bleeding gums

Method used

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  • Oral caring composition and application thereof in inhibiting gum bleeding
  • Oral caring composition and application thereof in inhibiting gum bleeding
  • Oral caring composition and application thereof in inhibiting gum bleeding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0130] A kind of oral care composition, configured according to the formula in the table.

[0131] Example 1 Example 2 Example 3 Example 4 Example 5 Asiaticoside 0.01 0.1 1 3 4 normal saline Add to 100% Add to 100% Add to 100% Add to 100% Add to 100%

[0132] After testing, the conclusions are as follows:

[0133] Example 1 Example 2 Example 3 Example 4 Example 5 PT(s) 13.9 12.77 11.27 10.11 10.19 TT(s) 41.42 39.08 36.49 33.18 33.2 APTT(s) 24.9 25.07 23.25 20.33 20.41 platelet aggregation rate 53.8 54.6 63.8 66.05 66.17

[0134] As can be seen from Examples 1-5, the oral care composition of the present invention can reach four indicators of coagulation: prothrombin time (PT)≤14.5 seconds; thrombin time (TT)≤42.5 seconds; activated partial thromboplastin time Time (APTT) ≤ 27.0 seconds; platelet aggregation rate ≥ 53.5. When the mass ratio of asiaticoside is 1-3%, th...

Embodiment 6-10

[0136] A kind of oral care composition, formula configuration according to the table:

[0137] Example 6 Example 7 Example 8 Example 9 Example 10 Madecassoside 0.01 0.1 1 3 4 normal saline Add to 100% Add to 100% Add to 100% Add to 100% Add to 100%

[0138] The four items of blood coagulation in the above-mentioned oral care composition are tested, and the conclusions are as follows:

[0139] Example 6 Example 7 Example 8 Example 9 Example 10 PT(s) 13.78 11.24 11.82 10.27 10.25 TT(s) 41.05 40.23 34.01 33.79 33.82 APTT(s) 24.43 24.05 21.37 19.41 19.5 platelet aggregation rate 56.2 55.2 62.2 65.77 65.81

[0140] As can be seen from Examples 6-10, four indicators of blood coagulation in the oral care composition containing madecassoside can be achieved: prothrombin time (PT)≤14.5 seconds; thrombin time (TT)≤42.5 seconds; activation Partial thromboplastin time (APTT) ≤...

Embodiment 11-13

[0142] A kind of oral care composition, formula configuration according to the table:

[0143] Example 11 Example 12 Example 13 Asiatic acid 0.01 0.1 1 normal saline Add to 100% Add to 100% Add to 100%

[0144] The four items of blood coagulation in the above-mentioned oral care composition are tested, and the conclusions are as follows:

[0145] Example 11 Example 12 Example 13 PT(s) 14.21 12.66 11.42 TT(s) 42.15 40.44 37.71 APTT(s) 25.34 26.61 25.07 platelet aggregation rate 54.19 56.63 59.68

[0146] As can be seen from Examples 11-13, the oral care composition containing asiatic acid can achieve four blood coagulation indicators: prothrombin time (PT)≤14.5 seconds; thrombin time (TT)≤42.5 seconds; activated partial coagulation Active enzyme time (APTT) ≤ 27.0 seconds; platelet aggregation rate ≥ 53.5.

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Abstract

The invention discloses an oral caring composition which comprises asiatic centella triterpenoids and an orally acceptable carrier, wherein the triterpenoids comprise one of or a combination of more of asiaticoside, asiaticoside degradation products, hydroxy asiaticoside and hydroxyl asiaticoside degradation products. The invention further discloses application of the asiatic centella triterpenoids in inhibiting gum bleeding. Four blood coagulation indexes of the oral caring composition disclosed by the invention meet standards that the prothrombin time (PT) is less than or equal to 14.5 seconds, the thrombin time (TT) is less than or equal to 42.5 seconds, the activated part thromboplastin time (APTT) is less than or equal to 27.0 seconds, and the platelet aggregation rate is greater thanor equal to 53.5. The problem of gum bleeding can be effectively solved.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to an oral care composition and its application in inhibiting gum bleeding. Background technique [0002] Bleeding gums is a common oral problem and a symptom of periodontal problems. The common cause is chronic inflammation of the gums: after the gums are infected by plaque bacteria and stimulated by local calculus, the blood vessels expand, the tissue becomes congested, and the texture of the gums becomes brittle, causing gum soft tissue The inflammatory reaction of the patient will bleed after a little external force. If left unattended, gingivitis will slowly develop into periodontitis, the alveolar bone around the root of the tooth will gradually be destroyed, the tooth will lose its support, slowly loosen, shift or even fall off, and it will also cause other diseases. [0003] The fourth national oral epidemiological survey report shows that the detection rate of gingival b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P1/02A61P7/04A61K8/63A61Q11/00
CPCA61K31/7024A61P1/02A61P7/04A61K8/63A61Q11/00
Inventor 周艺霍双君陈晓斌
Owner HAWLEY & HAZEL BVI
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