Schizophrenia gene-gene interaction network and construction method thereof

Abstract

The invention discloses a construction method of a schizophrenia gene-gene interaction network. The construction method comprises the following steps: (1), collecting known schizophrenia candidate genes; (2) mapping the collected known schizophrenia candidate genes into a human protein-protein interaction network, and converting the human protein-protein interaction network into an interaction network named by genes; (3) carrying out R-score assignment on all the genes in the network, carrying out G-score assignment on all the genes in the network, and endowing each edge with a weight; (4) constructing an inter-node shortest path matrix and extracting a preliminary network by using a walk extension method; and (5), extracting a final network and outputting a result. According to the schizophrenia gene-gene interaction network constructed by the invention, part of false positive genes are removed, more potential candidate genes related to schizophrenia are included, and an enrichment analysis result shows that the retained genes are more related to schizophrenia, so that the constructed gene interaction network is better in quality.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a schizophrenia gene-gene interaction network and a construction method thereof. Background technique [0002] Schizophrenia is a heritable psychiatric disorder characterized by positive and negative manifestations and symptoms and cognitive dysfunction that usually begins in early adulthood and often persists throughout life. In recent years, the research hotspots of schizophrenia mainly focus on the search of candidate genes for pathogenicity. These research results show that schizophrenia has a high degree of genetic heterogeneity. [0003] The traditional method of finding risk genes in disease signaling pathways is to detect protein-protein interactions, such as the study of DISC1. However, for schizophrenia, which has a large number of disease-causing genes, it is not only inefficient to conduct functional studies on individual genes, but also has to be done. Infor...

AI Technical Summary

Problems solved by technology

[0003] The traditional method of finding risk genes in disease signaling pathways is to detect protein-protein interactions, such as the study of DISC1. However, for schizophrenia, which has a large number of disease-causing genes, it is not only inefficient to conduct functional studies on individual genes, but also has to be done. information about the coordination and interaction between genes

There are also some studies that have mapped mutations to the KEGG signaling pathway and found that risk genes are enriched in the cell adhesion molecule pathway, but the signaling pathway does not act alone, and many other molecular pathways will also participate in it, and the pathogenic mechanism of most of the current mutations is not known. It is unclear and no one has systematically studied the pathogenic pathways of schizophrenia caused by mutations in pathogenic candidate genes of schizophrenia

Images