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Living organism oxygen self-production photosensitizer and application thereof

A technology of photosensitizer and oxygen quantity, applied in the field of biomedicine, can solve the problems of no tumor targeting or poor controllability, complex preparation process and high cost, and achieve the effects of improving delivery efficiency, simple process and low cost.

Inactive Publication Date: 2020-02-21
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned new photosensitizers have a single function, complex preparation process, high cost, professional equipment and complex conditions, and no tumor targeting or poor controllability. These defects greatly limit the use of photosensitizers. Large-scale clinical application

Method used

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  • Living organism oxygen self-production photosensitizer and application thereof
  • Living organism oxygen self-production photosensitizer and application thereof
  • Living organism oxygen self-production photosensitizer and application thereof

Examples

Experimental program
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Effect test

Embodiment

[0038] Prepare for the experiment: Prepare a 500ml Erlenmeyer flask, pour cyanobacteria and sterilized BG11 medium into the aseptic operating table, seal the bottle mouth with a breathable parafilm, and place it in the sun for cultivation and amplification.

[0039] Experiment 1: The cyanobacteria were placed under different wavelengths of light (darkness, LED, 660nm laser, 808nm laser) and different colony densities, and the oxygen content in the solution was monitored by an oxygen meter. The result is as Figure 1-2 As shown, it is found that the cyanobacteria with the same density produce the most oxygen under the irradiation of the wavelength 660nm laser, and under the same 660nm laser irradiation, the greater the density of the cyanobacteria, the more the oxygen production.

[0040] Experiment 2: In anoxic BG11 medium solution, the density of cyanobacteria is 2×10 8 CFU / mL (number of colonies / ml), add a probe for singlet oxygen detection (SOSG) to each well in advance, a...

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Abstract

The invention discloses a new function of cyanobacteria naturally existing in nature, and aims to provide a photosensitizer with a simple preparation process, overcome a tumor hypoxia microenvironmentthrough oxygen self-production by utilizing the characteristic that cyanobacteria generates oxygen through photosynthesis after being illuminated, and target tumors to play an effective photodynamicrole. The in-vitro experiments prove that the cyanobacteria can effectively inhibit the growth of 4T1 cells after being irradiated by laser with a wavelength of 660nm. The photosensitizer is simple inprocess step and low in cost, only a large amount of cyanobacteria needs to be simply multiplied and cultured, and oxygen can be supplied to the photosensitizer by providing specific illumination, sothat tumor hypoxia is overcome, the photodynamic therapy effect is achieved, and the photosensitizer capable of generating oxygen by itself and having industrial practical value is developed.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an economical, rapid and mass-proliferative and amplified photosensitizer that is not dependent on oxygen and can target tumors, and can be used for photodynamic therapy. Background technique [0002] Cancer has become one of the important diseases that threaten human health worldwide. The existing mainstream cancer treatment methods include surgical resection, chemical drug therapy, and radiotherapy, but these treatments have their own limitations. In recent years, the development of nanoscience and technology has opened up a new means and method for the medical field, especially for the treatment of cancer. Tumor phototherapy is a new cancer treatment method with good specificity and non-invasiveness that has been widely studied in recent years. According to its specific mechanism of action, it can be divided into photothermal therapy (Photothermal Therapy, PTT) and photo...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00A61P35/02
CPCA61K41/0052A61K41/0057A61P35/00A61P35/02
Inventor 蔡林涛刘兰兰何华美周海梅
Owner SHENZHEN INST OF ADVANCED TECH
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