Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases

Abstract

Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1,Z2, the ring system denoted by "a", R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having amutant KRAS gene.

Description

[0001] Cross references to related applications [0002] This application claims the priority rights of U.S. Provisional Application Patent No. 62 / 428,274 filed on November 30, 2016, which is hereby incorporated by reference in its entirety. Technical field [0003] The present disclosure relates to the field of compounds, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions. More specifically, the present disclosure relates to methods of using certain compounds to treat hyperproliferative disorders such as cancer. Background technique [0004] Cancer is uncontrolled cell proliferation and is a multifactorial disease characterized by tumor formation, growth, and in some cases metastasis. In the United States, more than 1.5 million people will be diagnosed with cancer this year, and more than 500,000 people will die of cancer. Overall, it is estimated that at least one in three people will develop some form of cancer in their life...

AI Technical Summary

Problems solved by technology

Cancer cells can reprogram their glucose metabolism, and thus their energy production, by limiting most of their energy metabolism to glycolysis, a reprogramming that was considered primitive and inefficient by early biochemists.

Images