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Anti-HPV type vaginal temperature-sensitive gel, preparation method and application thereof.

A temperature-sensitive gel and vaginal technology, which can be applied to non-active ingredient medical preparations, active ingredient-containing medical preparations, antibacterial drugs, etc., can solve the problems of not having anti-HPV effects, and achieve enhanced coverage protection and lubrication Sexuality, strong killing effect, high compliance effect

Inactive Publication Date: 2020-02-04
刘志鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides an anti-HPV type vaginal temperature-sensitive gel, its preparation method and application, so as to solve the technical problem that the conventional vaginal gel does not have anti-HPV efficacy in the prior art

Method used

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  • Anti-HPV type vaginal temperature-sensitive gel, preparation method and application thereof.
  • Anti-HPV type vaginal temperature-sensitive gel, preparation method and application thereof.

Examples

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Effect test

Embodiment 1

[0032] The temperature-sensitive gel for anti-HPV vagina includes the following components by weight: 10 parts of poloxamer, 0.05 part of chitosan, 0.1 part of chlorhexidine gluconate, and 1 part of giant salamander oligosaccharide peptide; The thermosensitive gel contains 1 million IU of recombinant human interferon; the anti-HPV vaginal thermosensitive gel contains 1 μg / mL cell growth factor.

Embodiment 2

[0034] The thermosensitive gel for anti-HPV type vagina includes the following components by weight: 30 parts of poloxamer, 1 part of chitosan, 1 part of chlorhexidine gluconate, and 5 parts of giant salamander oligosaccharide peptide; The thermosensitive gel contains 10 million IU of recombinant human interferon; the anti-HPV vaginal thermosensitive gel contains 100 μg / mL cell growth factor.

Embodiment 3

[0036]The thermosensitive gel for anti-HPV type vagina includes the following components in weight percentage: poloxamer 10%-30%, chitosan 0.05%-1%, chlorhexidine gluconate 0.1%-1%, giant salamander oligosaccharide peptide 1%-5%; the anti-HPV vaginal thermosensitive gel contains 1 million to 10 million IU recombinant human interferon; the anti-HPV vaginal thermosensitive gel contains 1-100 μg / mL cell growth factor.

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Abstract

The invention provides anti-HPV type vaginal temperature-sensitive gel, a preparation method and application thereof. The temperature-sensitive gel includes poloxamer, chitosan, chlorhexidine gluconate, giant salamander oligosaccharide peptides, recombinant human interferons and cell growth factors at the specific ratio, and on this basis, antiviral drugs, antibacterial drugs, antimycotic drugs, antifungal drugs, antimycoplasma drugs and other functional components can be further added. The temperature-sensitive gel is a sustained release preparation with a pH value consistent with the vaginalenvironment, when the temperature is lower than 28 DEG C, the temperature-sensitive gel is in a liquid state, can penetrate into deep folds of the uterus and the vagina and kill pathogens, gel is formed after making contact with the body temperature for 3-5 minutes to cover the disease part, and is not prone to overflowing, and action time and action concentration of the drug and the drug receiving part are guaranteed to the maximum extent; meanwhile, the gel can block the protein synthesis of human papillomavirus (HPV) E6 and E7, and inhibit the proliferation of HPV; and meanwhile, high bactericidal effects on gram-positive bacteria, gram-negative bacteria and fungi are achieved.

Description

technical field [0001] The invention relates to the technical field of gynecological external medicines, in particular to an anti-HPV vaginal temperature-sensitive gel, its preparation method and application. Background technique [0002] Women's vagina is naturally warm and humid, with a lot of secretions, and it is easy to breed microorganisms. Therefore, vaginal care is an important means to ensure women's health. Among vaginal care products, lotions, suppositories, and traditional gels are the most widely used dosage forms; among them, lotions are liquid preparations. Although they can wash the vagina, the lotions are easy to overflow outside the body, resulting in too short local action time. The bactericidal effect is poor; and frequent use of a large amount of lotion to clean the reproductive tract will destroy the natural protection mechanism of the vagina, destroy the ecological balance in the vagina, and easily produce negative effects. Suppositories have good loc...

Claims

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Application Information

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IPC IPC(8): A61K38/21A61K45/06A61K9/06A61K47/36A61P31/20A61P15/02A61P31/02A61P31/04A61P31/10A61P33/02A61K38/18A61K38/14A61K31/155
CPCA61K9/0034A61K9/06A61K31/155A61K38/14A61K38/18A61K38/21A61K45/06A61K47/36A61P15/02A61P31/02A61P31/04A61P31/10A61P31/20A61P33/02A61K2300/00
Inventor 刘志鹏徐俊
Owner 刘志鹏
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