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Method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in ionic liquid

A technology of phenylalanine ester and ionic liquid, which can be used in drug combination, antitumor drugs and other directions, can solve problems such as solubility problems, and achieve the effect of improving biological activity

Inactive Publication Date: 2020-01-21
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to construct a homogeneous xylan reaction system, the solubility problem caused by intramolecular and intermolecular hydrogen bonds must first be solved

Method used

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  • Method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in ionic liquid
  • Method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in ionic liquid
  • Method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in ionic liquid

Examples

Experimental program
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Effect test

Embodiment

[0040] (1) Measure 18mL of analytically pure N-methylimidazole and 22mL of analytically pure chloroethanol into a 250mL four-neck flask, heat the system to 70°C in an oil bath, and stir for 36 hours to obtain the ionic liquid chloride-1- (2-Hydroxyethyl)-3-methylimidazole ([Hemim]Cl).

[0041] (2) After the reaction in step (1) was completed, the obtained material was cooled to room temperature, and placed in a refrigerator at 5°C for 15 hours to precipitate a precipitate, which was filtered, washed with 15 mL of analytically pure ethyl acrylate, and suction filtered 3 times. The filter cake was put into a watch glass, dried in a constant temperature vacuum oven at 50°C for 24 hours, taken out and cooled to room temperature to obtain 1-(2-hydroxyethyl)-3-methylimidazole chloride as a solid ionic liquid at room temperature.

[0042] (3) 12 g of bagasse xylan was dried in a vacuum constant temperature drying oven at 50° C. for 24 hours to a constant weight to obtain dry-based ba...

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Abstract

The invention discloses a method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in an ionic liquid. The method comprises the following steps: by taking bagasse xylan as a main raw material, by taking vinyl acetate (VAc) as a grafting monomer and in a chlorinated-1-(2-hydroxyethyl)-3-methylimidazole ionic liquid solvent obtained by reaction of N-methylimidazole and chloroethanol, synthesizing bagasse xylan-g-VAc through initiation of ammonium sulfate; then by taking BOC-L-phenylalanine (tert-butyloxycarboryl-L-phenylalanine) subjected to acylating chlorination as an esterifyingagent, and taking 4-dimethylaminopyridine (DMAP) and cobalt naphthenate as a composite catalyst, carrying out catalytic esterification to synthesize a composite modified derivative that is the L-phenylalanine esterified bagasse xylan-g-VAc. The xylan derivative is endowed with specific activity to tumor cells, so that the xylan derivative has potential application value in the field of medicines.

Description

technical field [0001] The invention relates to the field of fine chemical industry, in particular to a method for synthesizing L-phenylalanine esterified bagasse xylan-g-VAc in ionic liquid. Background technique [0002] Xylan is a green biomass resource that is widely distributed in nature, renewable, and has high added value. The modified xylan has significant changes in its molecular structure and physical and chemical properties. Biological activities such as tumor and immune regulation were significantly improved. In recent years, scholars at home and abroad have increased the active groups of xylan through a series of chemical modifications such as etherification, oxidation, amination, esterification, and graft copolymerization to obtain higher biological activity. However, most of the current researches are simple or one-step modification of xylan, and there are few literature reports on the study of compound modified xylan. [0003] The physical and chemical prope...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F218/08C08F8/32A61P35/00
CPCA61P35/00C08F8/32C08F251/00C08F218/08
Inventor 李和平杨锦武李明坤葛文旭张淑芬郑光绿柴建啟武晋雄耿恺杨莹莹
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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