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Absorbable suture for obstetrics and gynecology

A suture, obstetrics and gynecology technology, applied in the field of medical sutures, can solve the problems of restricting tissue ingrowth, slow degradation of polylactic acid, difficult suture performance regulation, etc., to achieve good biocompatibility and promote inward growth The effect of growth healing and avoiding secondary cracking

Active Publication Date: 2020-06-02
刘金娥 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent uses too many types of raw materials, and each raw material is simply mixed, and the effect is not clear, so it is difficult to effectively control the performance of the suture; at the same time, due to the slow degradation rate of polylactic acid, although it can maintain a high strength, However, the resulting suture continues to maintain a relatively tight structure inside, limiting tissue ingrowth, thereby prolonging the healing time and affecting the healing effect

Method used

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  • Absorbable suture for obstetrics and gynecology
  • Absorbable suture for obstetrics and gynecology
  • Absorbable suture for obstetrics and gynecology

Examples

Experimental program
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preparation example Construction

[0034] The present invention also provides a preparation method of absorbable suture for obstetrics and gynecology, comprising the following steps:

[0035] S1, dissolving chitosan in a mixed solution containing acetic acid and urea, obtaining a spinning solution after filtering and degassing, and preparing chitosan threads by wet spinning;

[0036] S2. Mix lactic acid solution with polyethylene glycol solution, prepare polylactic acid by solution polycondensation method, then mix and heat the prepared polylactic acid and chitosan to obtain chitosan graft modified polylactic acid, and use melting Modified polylactic acid yarns are prepared by spinning;

[0037] S3. Take 1 strand of chitosan thread obtained in step S1 as the core thread, and take 6 to 8 strands of the modified polylactic acid thread obtained in step S2 as the shell thread, and use a braiding machine to carry out ply braiding to obtain a braided thread;

[0038] S4. After mixing calcium stearate and polylactic ...

Embodiment 1

[0043] This embodiment provides a method for preparing absorbable suture for obstetrics and gynecology, comprising the following steps:

[0044] S1. The degree of deacetylation of 5g is 90%, and the relative molecular mass is >1.0×10 6 Chitosan is dissolved in the mixed solution that contains acetic acid and urea in 100g, and the massfraction of acetic acid is 5% in the described mixed solution, and the massfraction of urea is 2%; Make chitosan solution after fully stirring, then to After filtering and removing air bubbles, the spinning solution is obtained, which is sprayed out through a spinneret, and then coagulated and stretched to obtain chitosan threads with a diameter of 0.1 mm;

[0045] S2. Mix the lactic acid solution with a concentration of 88% and the polyethylene glycol solution with a concentration of 50% in a mass ratio of 1:1, heat at 70°C for 2 hours to remove water, and then heat the mixture under N 2 Heat the oil bath to 120°C under the atmosphere. After pre...

Embodiment 2~4 and comparative example 1~2

[0057] Embodiments 2 to 4 and Comparative Examples 1 to 2 respectively provide a method for preparing absorbable sutures for obstetrics and gynecology. The number of strands of the wire; the corresponding core wire diameters, shell wire diameters and shell wire strands in each embodiment and comparative example are shown in Table 2.

[0058] Table 2 The core wire diameter, shell wire diameter and shell wire strands corresponding to Examples 2~4 and Comparative Examples 1~2

[0059]

[0060] The mechanical properties, antibacterial properties and degradation properties of the absorbable sutures for obstetrics and gynecology prepared in Examples 2-4 and Comparative Examples 1-2 were tested, and the results are shown in Table 3.

[0061] Table 3 Performance parameters of absorbable sutures for obstetrics and gynecology prepared in Examples 2-4 and Comparative Examples 1-2

[0062]

[0063] It can be seen from Table 3 that changing the diameter of the core wire, the diamete...

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Abstract

The invention discloses strile absorbent sutures for gynaecology and obstetrics and a preparation method of the strile absorbent sutures. The strile absorbent sutures for the gynaecology and obstetrics are prepared by taking chitosan silk threads as core threads, taking modified polylactic acid silk threads as shell threads, after stranding braiding, immersing the chitosan silk threads and the modified polylactic acid silk threads into coating liquid containing calcium stearate and polylactic acid and drying the liquid. Through the preparation method, the mechanical properties and hydrophilicproperties of the polylactic acid can be improved, and the prepared sutures have high strength and good biocompatibility; chitosan in the inner part of the sutures degrades slowly, while long-term antibacterial action is achieved, the sutures can further gradually form a hollow structure, thus ingrowth and healing of tissue is promoted, and the effect of accelerating the healing of the tissue is achieved; and the overall preparation process is simple and convenient to control, and needs of practical production and application can be met.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable suture for obstetrics and gynecology. Background technique [0002] In the clinical diagnosis and treatment of obstetrics and gynecology, surgery plays an irreplaceable role, and suture, as one of the necessary materials for suturing incisions after surgery, is of great significance in accelerating incision healing and reducing postoperative complications. At present, sutures are generally divided into absorbable sutures and non-absorbable sutures. Among them, absorbable sutures are not only non-toxic, non-irritating, and highly compatible, but also have good biodegradability and can be degraded and absorbed by the human body. It is painful to remove the stitches and enhance the aesthetic effect of the operation, so it is widely used in clinical suture, especially in obstetrics and gynecology, to meet the needs of doctors and patients. [0003] At present, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/12A61L17/14
CPCA61L17/10A61L17/12A61L17/145A61L2400/18A61L2420/02
Inventor 刘金娥张曰莲李明美王时灿
Owner 刘金娥
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