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A kind of w/o/w type multiple emulsion and preparation method thereof

A technology of multiple emulsions and total weight, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the complex and changeable cosmetics, and it is difficult to prepare multiple emulsions for long-term stable storage, so as to prolong the use and storage time , the preparation method is simple, the effect of low cost

Active Publication Date: 2022-06-24
瑞希(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the cosmetic formula is complex and changeable, and it is difficult to prepare multiple emulsions that can be stored stably for a long time

Method used

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  • A kind of w/o/w type multiple emulsion and preparation method thereof
  • A kind of w/o/w type multiple emulsion and preparation method thereof
  • A kind of w/o/w type multiple emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A W / O / W type multiple emulsion, by weight percentage, the multiple emulsion includes the following components: hydrophilic surfactant (sodium lauryl sulfate 0.5%, Tween 80 1%) 1.5%, hydrophilic surfactant Oil-based surfactant (decapolyglycerol decaoleate) 1%, active ingredient (sunscreen [bis-ethylhexyloxyphenol methoxyphenyl triazine]) 3%, acceptable excipients in external preparations for skin (oil Phase [paraffin] 3%, stabilizer [polyvinyl alcohol] 0.75%, antioxidant [tocopheryl acetate] 0.5%, preservative [propylparaben] 1%) 5.25%, the balance is purified water. The multiple emulsions were prepared as follows:

[0025] (1) according to the weight percent of each component in the above-mentioned multiple emulsion, take by weighing hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (deca polyglycerol tenoleate) , active ingredients (sunscreens [bis-ethylhexyloxyphenol methoxyphenyltriazine]), excipients acceptable in topical skin prepara...

Embodiment 2

[0028] A W / O / W type multiple emulsion, by weight percentage, the multiple emulsion includes the following components: hydrophilic surfactant (sodium lauryl sulfate 1%, Tween 80 2%) 3%, hydrophilic Oily surfactant (deca polyglycerol decaoleate) 2%, active ingredient (whitening and freckle removing agent [potassium methoxysalicylate]) 3%, acceptable excipients in external preparations for skin (oil phase [tetradecanoic acid]) isopropyl ester] 5%, stabilizer [polyvinyl alcohol] 1%, antioxidant [sodium metabisulfite] 2.5%, preservative [phenoxyethanol] 1%) 9.5%, and the balance is purified water. The multiple emulsions were prepared as follows:

[0029] (1) according to the weight percent of each component in the above-mentioned multiple emulsion, take by weighing hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (deca polyglycerol tenoleate) , Active ingredients (whitening and freckle removal agent [potassium methoxysalicylate]), acceptable excipien...

Embodiment 3

[0032] A W / O / W type multiple emulsion, by weight percentage, the multiple emulsion includes the following components: hydrophilic surfactant (sodium lauryl sulfate 0.8%, Tween 80 1.6%) 2.4%, hydrophilic surfactant Oily surfactant (deca polyglycerol decaoleate) 1.6%, active ingredients (whitening and freckle removing agent [ethyl ascorbic acid] 5%, anti-aging agent [tea polyphenol] 10%) 15%, acceptable in skin external preparations Excipients (oil phase [paraffin] 4%, stabilizer [sodium polymethacrylate] 0.5%, antioxidant [tocopherol] 1%, preservative [sorbitol] 1%) 6.5%, the balance is purified water . The multiple emulsions were prepared as follows:

[0033] (1) according to the weight percent of each component in the above-mentioned multiple emulsion, take by weighing hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (deca polyglycerol tenoleate) , Active ingredients (whitening and freckle removal agent [ethyl ascorbic acid], anti-aging agent ...

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Abstract

The invention relates to a W / O / W type multiple emulsion and a preparation method thereof, belonging to the technical field of cosmetics. The multiple emulsion comprises the following components in terms of weight percentage: 1.5-3% of hydrophilic surfactant, lipophilic surface 1-2% of active agent, 0.1-20% of active ingredient, 2.1-26% of acceptable excipients in the skin external preparation, and the balance is water. The multiple emulsion is prepared by a two-step emulsification method. During the preparation process, by reasonably controlling the types and amounts of the hydrophilic surfactant and the lipophilic surfactant, the HLB value of the prepared multiple emulsion can be finally controlled, and the final emulsion can be effectively improved. The formation rate and stability of the prepared multiple emulsion system, after a long period of storage, the oil layer area does not change. The preparation method of the multiple emulsion is simple, low in cost and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a W / O / W type multiple emulsion and a preparation method thereof. Background technique [0002] There are only two types of traditional emulsions: O / W type and W / O type. W / O type lotion has a bright appearance, good moisturizing and emollient effect, but it is easy to be sticky when applied, has poor skin feel, and is not easy to clean; while O / W type lotion has good spreadability and refreshing Skin feel, but the moisturizing effect and emollient effect are not as good as W / O type lotion. [0003] Multiple emulsions, also known as composite emulsions, referred to as double emulsions, are multi-layer emulsions formed by dispersing an emulsion (often called primary emulsion, or colostrum for short) in another continuous phase. Generally, they are highly dispersed and have different particle sizes. There are many types of multiphase systems, and the two most common t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/06A61K8/39A61K8/46A61K8/49A61K8/31A61K8/81A61K8/67A61K8/37A61Q19/00
CPCA61K8/066A61K8/39A61K8/463A61K8/4993A61K8/4966A61K8/31A61K8/8129A61K8/678A61K8/37A61Q19/00A61K2800/592A61K2800/805
Inventor 冯文学李杨洪
Owner 瑞希(重庆)生物科技有限公司
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