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Silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material, and preparation method and application of porous scaffold material

A silicon hydroxyapatite and porous scaffold technology, applied in medical science, prostheses, etc., can solve problems affecting skin function reconstruction, low degree of vascularization, difficult skin self-healing, etc., to achieve controllable biodegradability and Mechanical properties, enhanced cell adhesion, and reduced agglomeration effects

Active Publication Date: 2019-12-27
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The skin has a certain self-healing ability, but it is difficult for the skin to heal itself due to major trauma, severe burns, or great damage caused by metabolic diseases such as diabetes
At present, the research on skin tissue engineering scaffold and its role in skin repair has made great progress. Its structure is similar to human skin, and it has the function of isolation and protection of skin. General skin repair materials have good biocompatibility. However, the degree of vascularization of the current skin repair products is not high during the transplantation process, which affects the functional reconstruction of the skin to a certain extent. The key to skin function reconstruction

Method used

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  • Silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material, and preparation method and application of porous scaffold material
  • Silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material, and preparation method and application of porous scaffold material
  • Silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material, and preparation method and application of porous scaffold material

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Embodiment 1

[0050] A kind of silicon-doped hydroxyapatite-based porous scaffold material (PVA / HA-Si) of the present embodiment, the molecular formula of the scaffold material is Ca 10 (PO 4 ) 6-x (SiO 4 ) x (OH) 2-x , wherein: x=0.5, the mass ratio of PVA to HA-Si in the scaffold material is 1:40.

[0051] In this embodiment, the above-mentioned silicon-doped hydroxyapatite-based porous scaffold material for promoting vascularization is prepared by the following method, which specifically includes the following steps:

[0052] 1) Preparation of PVA solution: Weigh 0.4972g of polyvinyl alcohol, add 11mL of deionized water, stir magnetically at room temperature for 30min, put it in a water bath after swelling, and slowly raise the temperature to 85°C; continue stirring to dissolve completely; obtain the PVA solution; : the PVA molecular weight is 110000-130000Da; the mass fraction of PVA in the PVA solution is 4.3%.

[0053] 2) Preparation of PVA-CaCl 2 Solution: Weigh 0.0189g calciu...

Embodiment 2

[0058] A porous scaffold material based on silicon-doped hydroxyapatite to promote vascularization in this embodiment, the molecular formula of the scaffold material is Ca 10 (PO 4 ) 6-x (SiO 4 ) x (OH) 2-x , wherein: x=0.5, the mass ratio of PVA to HA-Si in the scaffold material is 1:40.

[0059] In this embodiment, the above-mentioned silicon-doped hydroxyapatite-based porous scaffold material for promoting vascularization is prepared by the following method, which specifically includes the following steps:

[0060] 1) Preparation of PVA solution: Weigh 0.4972g of polyvinyl alcohol, add 20mL of deionized water, stir magnetically at room temperature for 30min, put it in a water bath after swelling, and slowly raise the temperature to 85°C; continue stirring to dissolve completely; obtain a PVA solution; : the PVA molecular weight is 110000~130000Da; the mass fraction of PVA in the PVA solution is 2.4%.

[0061] 2) Preparation of PVA-CaCl 2 Solution: Weigh 0.0189g calci...

Embodiment 3

[0066] A porous scaffold material based on silicon-doped hydroxyapatite to promote vascularization in this embodiment, the molecular formula of the scaffold material is Ca 10 (PO 4 ) 6-x (SiO 4 ) x (OH) 2-x , where: x=0.25.

[0067] In this embodiment, the above-mentioned silicon-doped hydroxyapatite-based porous scaffold material for promoting vascularization is prepared by the following method, which specifically includes the following steps:

[0068] 1) Preparation of PVA solution: Weigh 0.4972g of polyvinyl alcohol, add 20mL of deionized water, stir magnetically at room temperature for 30min, put it in a water bath after swelling, and slowly raise the temperature to 85°C; continue stirring to dissolve completely; obtain a PVA solution; : the PVA molecular weight is 110000~130000Da; the mass fraction of PVA in the PVA solution is 2.4%.

[0069] 2) Preparation of PVA-CaCl 2 Solution: Weigh 0.0189g calcium chloride dihydrate and add it to 2.5mL deionized water, adjust ...

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Abstract

The invention discloses a silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material, and a preparation method and application of the porous scaffold material, and belongs to the technical field of biological materials. The silicon-doped hydroxyapatite based vascularization-promoting porous scaffold material has a molecular formula of Ca<10>(PO4)<6-x>(SiO4)<x>(OH)<2-x>,wherein x is more than 0 and less than 0.75. The stent material provided by the invention has directional gradient pores which are in communication along the radial direction, and meanwhile, the porescommunicate with each other, so that cell adhesion and regeneration are facilitated, and whole-layer skin repair related cells grow into the center from the edge and the bottom of a wound. In addition, the scaffold material prepared by the preparation method also has good biocompatibility, controllable biodegradability and mechanical property, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a silicon-doped hydroxyapatite-based porous scaffold material for promoting vascularization and its preparation method and application. Background technique [0002] The skin is the largest organ of the human body and acts as a barrier between the internal and external environment. The skin has a certain self-healing ability, but it is difficult for the skin to heal itself due to major trauma, severe burns, or extremely damaged skin caused by metabolic diseases such as diabetes. At present, the research on skin tissue engineering scaffold and its role in skin repair has made great progress. Its structure is similar to human skin, and it has the function of isolation and protection of skin. General skin repair materials have good biocompatibility. However, the degree of vascularization of the current skin repair products is not high during the transplantation pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/02A61L27/50A61L27/56A61L27/58A61L27/60
CPCA61L27/025A61L27/12A61L27/16A61L27/50A61L27/56A61L27/58A61L27/60C08L29/04
Inventor 李宾斌练辰希王欣宇
Owner WUHAN UNIV OF TECH
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