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Microneedle array dry electrode based on flexible substrate and preparation method of microneedle array dry electrode

A microneedle array and flexible substrate technology, applied in the field of medical devices, can solve the problems of not being able to penetrate the skin well, not being able to fit the human skin well, and low strength, and achieve good safety, low cost, and high strength Effect

Pending Publication Date: 2019-12-20
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, most of the microneedle dry electrodes currently prepared are rigid substrates, which cannot fit the human skin well. During the measurement process, the electrodes generate motion and friction relative to the skin, which introduces motion artifacts into the collected electrical signals. film
The invention patent of the prior art (patent application number CN201910027078.5) discloses "a flexible microneedle electrode array device and its preparation method". The flexible substrate and flexible microneedle electrodes in this technology use the same material polyimide , but the strength of polymer microneedles is lower than that of metal microneedles, and it is difficult to penetrate the skin

Method used

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  • Microneedle array dry electrode based on flexible substrate and preparation method of microneedle array dry electrode
  • Microneedle array dry electrode based on flexible substrate and preparation method of microneedle array dry electrode
  • Microneedle array dry electrode based on flexible substrate and preparation method of microneedle array dry electrode

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Experimental program
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Effect test

Embodiment 1

[0032] refer to Figure 9 , the method for preparing a metal microneedle array dry electrode based on a flexible substrate in this embodiment includes the following steps:

[0033] (1) if figure 1 As shown, a PDMS substrate 1 with multiple micro-through holes 2 that are not connected to each other is prepared by a one-time overmolding process, and the surface of the PDMS substrate 1 is silanized;

[0034] (2) Microneedles use commercial 0.12*5mm sterile stainless steel acupuncture needles, figure 2 The shown microneedles are arranged in a PDMS substrate 1 with micro-through holes 2, and the microneedles are perpendicular to the surface of the substrate 1 to form a square microneedle array; as image 3 As shown, each metal microneedle tip 4 is flush with the upper surface of the substrate 1, and the microneedle body 3 is located at the lower part of the substrate;

[0035] (3) Preparation of conductive prepolymer: mix conductive filler with PDMS or epoxy resin solution in a...

Embodiment 2

[0039] refer to Figure 9 , the method for preparing a metal microneedle array dry electrode based on a flexible substrate in this embodiment includes the following steps:

[0040] (1) Prepare substrate 1 with micro-through holes 2, such as Figure 6 Shown, preparation method is identical with embodiment 1;

[0041] (2) Microneedle fixation and arrangement: The microneedles are commercially available 0.12*5mm sterile stainless steel acupuncture needles, and the microneedles are arranged in the PDMS substrate 1 with micro-through holes 2 to form a circular microneedle array. The needle tip is flush with the upper surface of the substrate;

[0042] (3) Preparation of conductive prepolymer: mix conductive filler with PDMS or epoxy resin solution in a certain proportion; conductive filler can be carbon black, graphite, nano-silver. In this embodiment, conductive graphite is selected as the conductive filler, the main agent of PDMS and the curing agent are polymer solutions, and...

Embodiment 3

[0046] This embodiment is similar to Embodiment 2, except that the microneedles in this embodiment are titanium microneedles, and the heights of the microneedles exposed to the flexible substrate are different. Schematic diagram of the microneedle electrode Figure 8 shown.

[0047] It should be noted that the number, position, arrangement and height of the exposed flexible substrate are not limited to Figure 5 , Figure 7 , Figure 8 The situation shown can be adjusted arbitrarily according to actual needs.

[0048] In addition, in the prior art, silicon is generally used as the preparation material of microneedles, and the corresponding preparation method generally adopts photolithography and etching processes, but this method has the following disadvantages: (1) The preparation cost is high, and a clean room and photolithography are required. (2) The preparation process is complex, requiring steps such as gluing, exposure, development, and corrosion; (3) The material o...

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Abstract

The invention discloses a microneedle array dry electrode based on a flexible substrate and a preparation method of the microneedle array dry electrode. The method includes the steps that needle tipsof metal microneedles are inserted downwards into a base with a plurality of micro-through holes which are not connected with one another to form a microneedle array; the needle tips of the arranged microneedle array are placed upwards in a groove, and a conductive prepolymer is added into the groove to be solidified and molded into the flexible conductive substrate; and the substrate with the micro-through holes is separated from the conductive microneedle array, and the microneedle array dry electrode based on the flexible substrate is obtained. The microneedle array dry electrode includes the metal microneedle electrode array and the flexible conductive substrate, and the flexible conductive substrate is combined with the metal microneedles to prepare the microneedle dry electrode; andthe preparation method is simple, the cost is low, the microneedle electrode strength is high, the safety is high, long-time and high-efficiency signal acquisition is realized advantageously, and themicroneedle array dry electrode can be widely applied to the technical field of medical apparatus and instruments.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a microneedle array dry electrode based on a flexible substrate and a preparation method thereof. Background technique [0002] Physiological electrical signals mainly include myoelectricity, electrocardiogram, electroencephalogram, oculoelectricity and other signals, which can directly reflect the health status of a person and play an important role in medical diagnosis. It is the main monitoring object and physiological index basis in the process of clinical medical diagnosis, and has important guiding significance for the diagnosis and treatment of clinical diseases such as cardiovascular and cerebrovascular diseases and muscle dysfunction. Since physiological electrical signals are weak electrical signals, especially for ECG signals, which are about 1-100 μV, they are easily affected by noise, movement, etc. during the measurement process. Therefore, biomedical elect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0408
CPCA61B5/25
Inventor 鲁道欢李娟
Owner GUANGDONG PROV MEDICAL INSTR INST
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