Application of atractylolide I and analogues thereof to prevention and treatment of agriculture diseases

A technology of Atractylodes lactone and its analogues, which is applied in the field of natural medicinal chemistry, can solve problems such as no research reports on Atractylodes lactones and achieve high bactericidal activity

Inactive Publication Date: 2019-12-10
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the prevention and treatment of plant pathogenic fungi by Atractylodes macrolides

Method used

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  • Application of atractylolide I and analogues thereof to prevention and treatment of agriculture diseases
  • Application of atractylolide I and analogues thereof to prevention and treatment of agriculture diseases
  • Application of atractylolide I and analogues thereof to prevention and treatment of agriculture diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Chemical formulas (B1) to (B4) were isolated and their structures identified were consistent with those reported in literature. Atractylodes lactone I (B1) CAS: 73069-13-3, purity > 98%; Atractylodes lactone II (B2) CAS: 73069-14-4, purity > 98%; Atractylodes lactone III (B3) CAS: 73030 -71-4; atractylone (B4) CAS: 6989-21-5, purity>98%.

[0013]

Embodiment 2

[0014] Embodiment 2: Indoor antibacterial activity assay and result

[0015] The phytopathogenic bacteria used in this experiment were strains stored at 4°C in the laboratory, and the medium used was potato agar dextrose medium (abbreviated as PDA). PDA medium formula: potato (peeled) 200g, glucose 20g, agar 15g, distilled water 1000mL, natural pH.

[0016] Preparation method: Wash and peel the potatoes, weigh 200g and cut into small pieces, add water and boil until rotten (boil for 20-30 minutes, it can be pierced by a glass rod), filter with four layers of gauze and fill the beaker with water to 1000mL, According to the needs of the experiment, add 15-20g of agar, add 20g of glucose, stir to make it fully dissolved, then pack it in a triangular flask, sterilize at 121°C for 20 minutes, and cool it for later use.

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PUM

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Abstract

The invention belongs to the field of natural pharmaceutical chemistry, and discloses application of atractylolide I and analogues thereof (B1 to B4) to prevention and treatment of diseases caused byrhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum and magnaporthe oryzae. In particular, the atractylolide I has excellent inhibitory effect on the rhizoctonia solani, and can be used for preparing agricultural fungicides.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, discloses the new application of Atractylodes lactone I and its analogues, specifically relates to its prevention and treatment of Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Wheat scab, Rice Application in diseases caused by pestilence fungus. Background technique [0002] Plant disease is one of the main factors affecting agricultural production. According to the estimation of the Food and Agriculture Organization of the United Nations, the annual loss of grain and cotton production in the world is more than 10% due to disease. At present, the prevention and control of plant diseases in the world mainly uses chemical agents. However, due to the long-term use of chemical agents, a series of serious problems such as residues, pollution, resistance of harmful organisms, damage to non-target organisms and even ecological balance are caused. Therefore, The research and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/12A01P3/00
CPCA01N43/12
Inventor 刘映前孙钰赵文斌吴争荣秦芳王仁轩杨程杰彭静文
Owner LANZHOU UNIVERSITY
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