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Application of biflavonoids

A compound and drug technology, applied in the medical field, can solve the problem of not recording the treatment effect of enteritis, achieve good treatment effect, expand the scope of application, and improve the effect of symptoms

Inactive Publication Date: 2019-12-03
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no record in the prior art which single compound in traditional Chinese medicine has a good therapeutic effect on enteritis

Method used

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  • Application of biflavonoids
  • Application of biflavonoids
  • Application of biflavonoids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The compound shown in formula (2) is obtained by extracting from Garcinia cambogia seeds, and the specific operation is as follows: 5kg Garcinia cambogia fruit is pulverized, extracted with 95% ethanol, the filtrate is concentrated under reduced pressure to a paste, and the filter residue is refluxed with water to extract, and the filtrates are combined Concentrate under reduced pressure to a paste, extract the extract with n-butanol, ethyl acetate, and petroleum ether, respectively, and collect the n-butanol phase, ethyl acetate phase, and petroleum ether phase. The ethyl acetate phase was applied to a silica gel column, and the chloroform-methanol system was used as the eluent for gradient elution, and the compound was separated by Sephadex LH20 column chromatography and HPLC.

[0046] To characterize the compound:

[0047] White powder (methanol), C 30 h 22 o 10 , blue fluorescent light under 254nm ultraviolet light, yellow after color development with ethanol sul...

Embodiment 2

[0053] The compound shown in formula (3) is obtained by extracting from garcinia cambogia seeds, and the specific operation is as follows: 5 kg of garcinia cambogia kola nuts are pulverized, extracted with 95% ethanol, the filtrate is concentrated under reduced pressure to a paste, and the filter residue is extracted by adding water to reflux, and the filtrates are combined Concentrate under reduced pressure to a paste, extract the extract with n-butanol, ethyl acetate, and petroleum ether, respectively, and collect the n-butanol phase, ethyl acetate phase, and petroleum ether phase. The ethyl acetate phase was applied to a silica gel column, and the chloroform-methanol system was used as the eluent for gradient elution, and the compound was separated by Sephadex LH20 column chromatography and HPLC.

[0054] To characterize the compound:

[0055] Compound: white powder (methanol), C 30 h 22 o 11 , blue fluorescence under 254nm ultraviolet light, yellow after color developme...

experiment example 1GB1

[0060] Experimental example 1GB1a improves DSS-induced enteritis in mice

[0061] specific method:

[0062] 58 SPF grade C57BL mice, male, were randomly divided into 4 groups: control group, SASP (sulfasalazine) group (100mg / kg), DSS group, DSS+GB1a group (100mg / kg), and 10 normal groups , and the rest are 12 in each group. Mice in each group were given free access to drinking purified water for 3 days, and were induced by intragastric administration of SASP (100 mg / kg) and GB1a for 3 days in advance. From the 4th day to the 10th day, the mice in the control group drank normal saline freely, and the mice in the other groups drank 4% DSS (W / V) aqueous solution freely. The mice in the SASP group and the DSS+GB1a group continued to be gavaged for 7 days, and the experiment was ended on the 10th day. Blood was collected from the eyeballs of all mice, killed, dissected, and the colons were taken for detection of various indicators.

[0063] Symptom observation and pathological t...

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Abstract

The invention discloses an application of bioflavonoids, and mainly provides an application of a compound shown in the formula (I) to preparation of a colitis treatment drug, wherein R1 is hydrogen orhydroxyl. When the compound acts on DSS-induced enteritis of a mouse, it can be found that the compound can relieve symptoms of colitis of the mouse, the compound has a good therapeutic effect on colitis and can be applied to preparation of the colitis treatment drug, and the application range of the drug is expanded.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the application of a biflavonoid compound. Background technique [0002] Inflammatory bowel disease (enteritis) is a non-specific enteritis with unknown etiology, and it is one of the high-risk pathogenic factors inducing intestinal cancer, and has gradually developed into one of the five major epidemic diseases in the world. According to World Health Organization estimates, about 15% of patients with enteritis eventually lead to cancer occurrence and metastasis, seriously threatening the health and safety of patients. Therefore, controlling the occurrence and development of enteritis plays an important role in preventing intestinal cancer caused by inflammation. However, although many progresses have been made in the research of controlling enteritis and enteritis causing intestinal cancer for more than 20 years, until now, the clinical treatment effect of enteritis is still u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P1/00A61P1/04
CPCA61K31/353A61P1/00A61P1/04
Inventor 宋健平黄新安邓长生徐勤王琪张红英
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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