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Method for prolonging service life of reservoir-type dry powder inhalation drug supply device

A drug delivery device and a technology of powder mist, which is applied in the field of improving the service life of a storage-type powder spray drug delivery device, can solve problems such as poor powder fluidity, and achieve the goals of improving service life, preventing wear and sticking, and improving uniformity Effect

Active Publication Date: 2019-11-19
SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts a coaxial vibrating gear and a new vibrating tooth shape design, which can improve the shortcomings of poor powder fluidity by providing vibration force, and can ensure the need for multiple vibrations for multi-dose storage powder aerosols, and can prevent vibration gears The appearance of wear and sticking can significantly improve the service life of the vibration gear, thereby effectively prolonging the service life of the entire storage-type powder mist delivery device

Method used

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  • Method for prolonging service life of reservoir-type dry powder inhalation drug supply device
  • Method for prolonging service life of reservoir-type dry powder inhalation drug supply device
  • Method for prolonging service life of reservoir-type dry powder inhalation drug supply device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] For the vibrating gear of the vibrating gear and the vibrating tooth of the turntable, the second tooth surface adopts the conventional tooth surface generation form:

[0077] When the straight line R generated by the tooth surface does not intersect the rotation axis, the formula S R Both φ(t) and H(t) in (t)=φ(t)+H(t) are linear functions.

[0078] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0079] project 10 20 30 40 50 60 70 80 90 100 Example 1 device 1 1.6 1.6 1.7 1.7 2.1 5.3 N / A N / A N / A N / A Example 1 device 2 1.5 1.6 1.7 1.9 4.3 N / A N / A N / A N / A N / A Example 1 device 3 1.7 1.6 1.8 2.0 5.7 N / A N / A N / A N / A N / A Example 1 device 4 1.6 1.6 1.7 1.8 1.9 2.7 6.1 N / A N / A N / A Example 1 device 5 1.6 1.6 1.7 1.7 2.1 3.1 5.8 N / A N / A N / A Example 1 device 6 1.5 1.5 1....

Embodiment 2

[0084] When the straight line R generated by the tooth surface intersects the axis, the formula S R Both φ(t) and H(t) in (t)=φ(t)+H(t) are linear functions.

[0085] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0086]

[0087]

[0088] Note: 10, 20 to 100 represent the average torque recorded every ten times.

[0089] It can be seen from the data that the torque of the second tooth surface generated by this method does not show an increasing trend with the increase of the number of vibrations. The relative rotation torque of the vibrating gear and the vibrating teeth of the turntable is relatively average, but the average value is too large.

[0090] Disassemble the storage type powder mist dosing device, and observe that the tooth surfaces of the vibrating gear and the vibrating teeth of the turntable are relatively complete. The reason for the analysis is the curved surface o...

Embodiment 3

[0092] When the straight line R generated by the tooth surface intersects the axis, the formula S R In (t)=φ(t)+H(t), φ(t) is a quadratic function, and H(t) is a linear function.

[0093] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0094] project 10 20 30 40 50 60 70 80 90 100 Example 1 device 1 1.8 1.8 1.9 1.8 1.9 1.9 1.8 1.9 1.8 1.8 Example 1 device 2 1.8 1.9 1.8 1.7 1.8 1.9 1.8 1.9 1.8 1.8 Example 1 device 3 1.7 1.8 1.8 1..9 1.9 1.8 1.9 1.9 1.8 1.9 Example 1 device 4 1.8 1.9 1.9 1.8 1.9 1.9 1.8 1.7 1.8 1.8 Example 1 device 5 1.8 1.7 1.8 1.9 1.8 1.9 1.8 1.9 1.9 1.8 Example 1 device 6 1.8 1.9 1.9 1.8 1.9 1.9 1.8 1.9 1.8 1.9 Example 1 device 7 1.9 1.8 1.7 1.8 1.8 1.9 1.9 1.8 1.8 1.8 Example 1 device 8 1.8 1.8 1.9 1.8 1.8 1.9 1.8 1.8 1.9 1.8 Ex...

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Abstract

The invention relates to a method for prolonging the service life of a reservoir-type dry powder inhalation drug supply device, and belongs to the field of inhalation type drug supply devices. A toothsurface generating straight line with the length equal to the radius of a vibrating gear or a rotating disc is arranged; the tooth surface generating straight line starts from the position of the tooth bottom plane of the vibrating gear or the rotating disc, and the tooth surface generating straight line rotates and rises along the rotation axis at the same time; during rotating raising, on the opposite surface of the vibrating gear or the rotating disc, a sweeping method is adopted in the tooth surface generating straight line, and the tooth surface generating straight line is rotated a toothed curved surface of a second tooth surface of a lower vibration tooth or an upper vibration tooth. During the relative rotation of the vibration gear and the rotating disc, viewed in the radial direction of the rotation axis, a line contact structure form exists between the second tooth surfaces of the lower vibration tooth and the upper vibration tooth. According to the technical scheme of themethod for prolonging the service life of the reservoir-type dry powder inhalation drug supply device, the occurrence of abrasion and sticking can be prevented, and the service life of the second tooth surface of the vibration teeth is significantly prolonged, and the method for prolonging the service life of the reservoir-type dry powder inhalation drug supply device can be widely used in the field of designing and manufacturing of a vibration drug supply unit of the reservoir-type dry powder inhalation drug supply device.

Description

technical field [0001] The invention belongs to the field of devices for infusing a medium into or onto a human body, and in particular relates to a storage-type powder aerosol dosing device. Background technique [0002] Powder spray refers to micronized drug or in the form of capsules, vesicles or multi-dose reservoirs with carriers, using a special powder spray drug delivery device or inhalation device (or called an inhalation drug delivery device, also known as an inhalation drug delivery device in the past. Dry powder inhalation device or dry powder drug delivery device), a preparation form in which the patient actively inhales an aerosolized drug into the lungs. Inhalation powder spray relies on the patient's spontaneous breathing to make the drug powder enter the respiratory system, which has the characteristics of portability, low cost and strong stability. In recent years, the scope of application of inhaled powders has expanded from the traditional treatment of lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M15/00
CPCA61M15/0001
Inventor 谭中华卢望丁王然罗国军杜狄峥
Owner SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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