An anti-tumor quaternary ammonium salt derivative and its preparation method and application

A technology of quaternary ammonium salts and derivatives, applied in the field of medicine, can solve the problems of limited application scope and low anti-tumor activity, and achieve the effect of improving anti-tumor activity and high anti-tumor activity

Active Publication Date: 2020-09-25
SOUTHWEST UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Diosgenin and its derivatives are potential antitumor active substances, but their antitumor activity is still low, which largely limits their scope of application.

Method used

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  • An anti-tumor quaternary ammonium salt derivative and its preparation method and application
  • An anti-tumor quaternary ammonium salt derivative and its preparation method and application
  • An anti-tumor quaternary ammonium salt derivative and its preparation method and application

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Embodiment Construction

[0028] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0029] In the prior art, the effect of antitumor activity is poor.

[0030] The diosgenin quaternary ammonium salt derivatives provided in the embodiments of the present invention are represented by the following general formula (1):

[0031]

[0032] where R 1 , R 2 , R 3 is a hydrocarbon group or a substituted hydrocarbon group;

[0033] X=F, Cl, Br, I;

[0034] The preparation method of diosgenin quaternary ammonium salt derivatives provided in the embodiment of the present invention, the chemical reaction formula is:

[0035]

[0036] The present invention will be further described below in conjunct...

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Abstract

The invention belongs to the technical field of medicine, discloses an anti-tumor quaternary ammonium salt derivative, a preparation method and application thereof, a series of anti-tumor derivativesprepared through corresponding chemical reactions, and the application of the derivatives in anti-tumor. The present invention shows that all synthetic diosgenin quaternary ammonium salt derivatives have obvious inhibitory effect on the proliferation of A549 lung cancer cells, H1975 lung adenocarcinoma cells, Aspc-1 metastatic pancreatic cancer cells and A431 skin squamous carcinoma cells, and theantitumor activity of most derivatives is better than that of diosgenin, and the antitumor activity of most derivatives is better than that of diosgenin on Ramos B lymphoma cells.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antitumor quaternary ammonium salt derivative and a preparation method and application thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] Cancer is a major disease that threatens human life and health, and has become one of the important factors of human death. With the change of environment and lifestyle, the incidence and mortality of cancer in my country continue to rise. Therefore, exploring new antitumor drugs has become one of the important directions of new drug research and development. [0004] Natural active anti-tumor drugs have the advantages of obvious curative effect and less toxic and side effects. Diosgenin is rich in natural resources and has various pharmacological activities such as anti-tumor, hypolipidemic, anti-thrombotic, and anti-inflammatory. A large numb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00A61P35/00
CPCA61P35/00C07J71/0005
Inventor 杨鸿均曾倩倩马晓东王璐红迟福云
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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