Targeting development microbubble for tumor ultrasound treatment and preparation method thereof

Abstract

The invention relates to a targeting development microbubble for tumor ultrasound treatment. The targeting development microbubble comprises a lipid bilayer shell, a targeting polypeptide or protein derivative fixed at the outer side of the shell, a biological inert gas encased in the shell and blood coagulation factors and drug particles which are dispersed in the shell. The targeting developmentmicrobubble not only can perform high-frequency ultrasonic development to detect and diagnose tumors, but also can specifically adsorb tumor blood vessels through the targeting polypeptide or proteinderivative at the outer side of the lipid bilayer shell, and performs concentrated cavitation under the action of ultrasound to release the blood coagulation factors for rapidly forming capillary embolization, thereby achieving the purpose of treating the tumors. In addition, during microbubble cavitation, the drug particles are released into a tumor vascular embolization substance, so that a drug is slowly released, and the tumors are treated. The targeting development microbubble has extremely important significance for the diagnosis and treatment of the tumors. Furthermore, the invention relates to a preparation method of the targeting development microbubble for the tumor ultrasound treatment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a targeted imaging microbubble for ultrasonic treatment of tumors and a preparation method thereof. Background technique [0002] Malignant tumors have always been a problem that plagues the world, and its increasing morbidity and mortality are a major challenge to modern medicine. Tumor tissue is composed of two major system components: tumor blood vessels and tumor cells. The growth and metastasis of tumor cells depend on the formation of new blood vessels. New blood vessels not only provide nutrients and oxygen for the growth of tumor cells, but also effectively transport their metabolites. Without the formation of new blood vessels, the nutrient supply of tumor cells cannot be satisfied. And material excretion, and then severely limit the growth and metastasis of tumor cells. At present, anti-tumor vascular therapy has been considered as an important method f...

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Problems solved by technology

In addition, during the process of microbubble cavitation, the drug particles are released into the tumor vascular embolism material, so that the drug is released slowly, and at the same time of physical embolism, the tumor can be treated with drugs, which solves the problem of patent CN201110074404.1, which can only rely on drugs to treat tumors less effective problem

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