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mRNA vaccine delivery carrier and preparation method thereof

A technology for delivering vectors and vaccines, which is applied in the field of medicine and can solve the problem of insufficient delivery of mRNA

Active Publication Date: 2019-11-15
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the structure and physical and chemical characteristics of mRNA, the existing nanomaterials are still not effective enough for mRNA delivery, and the development and clinical application of mRNA-based tumor vaccines still face many problems.

Method used

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  • mRNA vaccine delivery carrier and preparation method thereof
  • mRNA vaccine delivery carrier and preparation method thereof
  • mRNA vaccine delivery carrier and preparation method thereof

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Embodiment Construction

[0036] Below in conjunction with accompanying drawing and specific embodiment the technical scheme of the present invention is described in further detail, but the present invention is not limited to following embodiment.

[0037] Unless otherwise specified, the reagents involved in the following can be purchased through commercial channels. For the sake of brevity, the parameters, steps and instruments used in some operations are not described in detail. It should be understood that these are well known and reproducible by those skilled in the art.

[0038]Lipid polymer C1 used in the present invention is a cationic lipid polymer, which is a lipid polymer with cationic properties in combination, and can self-assemble into nanospheres when it is mixed with mRNA and a stabilizer for nano-precipitation. Wrapped in the middle. The synthetic raw material of lipoid polymer C1 is polyamidoamine (PAMAM) dendrimer (polyamidoamine (PAMAM) dendrimer, PAMAM dendrimer; a kind of polymer ...

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Abstract

The present invention provides an mRNA vaccine delivery carrier which is a lipid polymer prepared by reacting a PAMAM dendritic polymer and 1,2-cyclododecane epoxide. The invention provides a preparation method of the mRNA vaccine delivery carrier. The mRNA vaccine delivery carrier provided by the invention has good specificity, good stability, high efficiency, and low toxicity, and is safe and effective.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an mRNA vaccine delivery carrier and a preparation method thereof. Background technique [0002] In recent years, cancer immunotherapy, including cancer vaccines, has made breakthroughs that have transformed cancer treatment and tumor biology. Therapeutic vaccines have shown great potential in the treatment of many types of tumors and infectious diseases. In the development of tumor vaccines, antigens are usually used as the main components of vaccines in the form of protein polypeptides and DNA plasmids for the development of traditional vaccines; now, vaccine treatments based on antigens in the form of mRNA (messenger RNA, messenger RNA) are also used. It has gradually been applied and has become a powerful substitute for conventional vaccine strategies. The synthesis of polypeptide antigens is costly and time-consuming; while the expression efficiency of DNA antigens is n...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/24A61K39/00A61P35/00
CPCA61K39/0011A61K47/24A61K47/34A61K2039/53A61P35/00
Inventor 夏小俊张红侠吴钧游欣如
Owner SUN YAT SEN UNIV CANCER CENT
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