Glossy ganoderma polysaccharide granules and preparation method and application thereof

Abstract

The invention relates to the technical fields of foods and drugs, and discloses glossy ganoderma polysaccharide granules and a preparation method and application thereof. The glossy ganoderma polysaccharide granules are prepared by granulating glossy ganoderma polysaccharide raw materials, an adhesion agent, auxiliary materials and an Arabic gum aqueous solution through a fluidization bed, whereinthe auxiliary materials are selected from one or two or more of chitosan hydrochloride, sodium starch phosphate and anhydrous calcium hydrogen phosphate. Through combination of appropriate auxiliarymaterials, through the compounding ratio of raw materials and auxiliary materials, and through combination with an appropriate fluidization bed granulation technology, the prepared glossy ganoderma polysaccharide granules are weak in moisture absorbing properties, good in flowing dispersibility, high in yield and high in medicine carrying amount, and favorable application prospects are provided for storage of glossy ganoderma polysaccharide and shaping of subsequent preparations. The method is low in equipment requirement, simple in technology, and short in production cycle, the production cost is greatly reduced, the production efficiency is improved, and the glossy ganoderma polysaccharide granules are suitable for mass production and application.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to a ganoderma polysaccharide granule and a preparation method and application thereof. Background technique [0002] Ganoderma lucidum polysaccharide is one of the most effective components in Ganoderma lucidum. It has anti-oxidation, hypoglycemic, hypolipidemic, immune regulation, anti-tumor, radiation protection and other pharmacological activities. It has broad application prospects in health food and drug development. [0003] Ganoderma lucidum polysaccharide is obtained from the solution obtained by water extraction of Ganoderma lucidum, and is prepared by spray drying, vacuum drying, belt drying or freeze drying. Bulk, poor fluidity and other shortcomings are not conducive to storage and subsequent formulation molding. [0004] At present, Ganoderma lucidum polysaccharide is mainly used in the preparation of tablets and capsules by wet granulation. During the wet g...

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Problems solved by technology

[0003] Ganoderma lucidum polysaccharide is obtained from the solution obtained by water extraction of Ganoderma lucidum, and is prepared by spray drying, vacuum drying, belt drying or freeze drying. Block, poor fluidity and other shortcomings, not conducive to storage and subsequent formulation molding

[0004] At present, Ganoderma lucidum polysaccharide is mainly used in the preparation of tablets and capsules by wet granulation. During the wet granulation process, the humidity of the granulation environment and the water content of the raw material of Ganoderma lucidum polysaccharide must be strictly controlled. At the same time, a large amount of fillers must be added. As a result, the drug loading capacity of Ganoderma lucidum polysaccharide is low, and the prepared particles have poor hygroscopicity and fluidity, and the molding rate is also low, and the particle size is different, which is not conducive to the storage of Ganoderma lucidum polysaccharide and subsequent formulation molding

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